Knowledge Tree
histone acetylation
Facts (7)
Sources
Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Apr 16, 2018 5 facts
referenceWellen et al. (2009) established that ATP-citrate lyase links cellular metabolism to histone acetylation.
referenceMoussaieff et al. (2015) showed that glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells.
claimCytosolic acetyl-CoA, derived from mitochondrial citrate, serves as the primary donor for histone acetylation, an epigenetic modification associated with transcriptional activation.
referenceSutendra G et al. found in 2014 that a nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation.
referenceCai et al. (2011) demonstrated that Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes.
The Problem of Hard and Easy Problems cambridge.org Mar 31, 2023 1 fact
claimDavid Chalmers' 'gene*' concept encompasses a wide range of biological and environmental factors, including chromosomes, plasmids, maternal RNA, transcription factors, DNA methylation, histone acetylation, mitochondria, and various environmental influences like drugs, pathogens, viruses, and prions.
Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 1 fact
claimThe Nrf2 pathway encompasses epigenetic modifications, including DNA methylation and alterations in histone acetylation, which sustain prolonged expression of antioxidant genes.