concept

hair follicle stem cells

Also known as: HFSCs, hair follicle stem cell

Facts (10)

Sources

Dietary interventions as regulators of stem cell behavior in ... genesdev.cshlp.org Genes & Development 7 facts

claimHair follicle stem cells (HFSCs) and intestinal stem cells (ISCs) rely on glycolysis to sustain proliferation.

claimCaloric restriction favors the preservation and function of muscle satellite cells, hematopoietic stem cells, and hair follicle stem cells in both young and old animals, according to studies by Cerletti et al. (2012), Tang et al. (2016), and Forni et al. (2017).

measurementIn mice, food intake restriction resulted in an increased hair follicle stem cell (HFSC) pool and decreased hair coat turnover, as reported by Forni et al. (2017).

referenceStem cells in muscle (satellite cells or MuSCs), bone marrow (hematopoietic stem cells or HSCs), and hair follicles (hair follicle stem cells or HFSCs) maintain a relatively quiescent state during homeostasis to preserve their self-renewing and tissue-regenerative capacity, as noted by Fuchs and Blau (2020).

claimCaloric restriction can reshape the local hair follicle stem cell (HFSC) niche by decreasing white adipose depots in the dermis.

claimAblation of PPARɣ in hair follicle stem cells (HFSCs) results in a phenotype similar to scarring alopecia with destruction of the pilosebaceous units, indicating the importance of this pathway to proper hair follicle homeostasis, as reported by Karnik et al. (2009).

referenceHair follicle stem cells (HFSCs) that cannot activate lactate dehydrogenase (LDH) activity fail to activate hair cycling, as LDH activity is required to sustain redox balance to promote glycolysis (Flores et al. 2017).

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 2 facts

claimShwartz et al. (2020) identified that cell types promoting goosebumps form a niche that regulates hair follicle stem cells.

claimLactate dehydrogenase activity drives the activation of hair follicle stem cells, as reported in a 2017 study in Nature Cell Biology.

18 research advances only possible here at UT MD Anderson mdanderson.org UT MD Anderson Dec 16, 2025 1 fact

claimIn a study led by Yejing Ge, Ph.D., and published in the journal Cell, researchers found that the epigenetic regulator SETBD1 drives retrotransposon suppression and protects the regeneration of hair follicle stem cells in preclinical models.