Knowledge Tree
genome integrity
Facts (4)
Sources
Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Apr 16, 2018 3 facts
claimMitochondria regulate cell death pathways, which allows stem cells to preserve genome integrity and the functionality of differentiated progeny.
claimOxidative stress, occurring when free radicals are not properly counterbalanced by cellular antioxidant defenses, is the primary cause of loss of genome integrity.
claimStem cells require constant and tight regulation of cell death to preserve genome integrity and ensure the faithful derivation of functional progeny.
Female reproductive system en.wikipedia.org 1 fact
claimOocytes residing in the primordial follicle of the ovary are in a non-growing prophase arrested state, but are capable of highly efficient homologous recombinational repair of DNA damages, including double-strand breaks, which helps maintain genome integrity and protect offspring health.