concept

FTO

Also known as: m(6)A mRNA demethylase FTO, fat mass and obesity-associated protein, FTO protein

Facts (7)

Sources

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 7 facts

referenceZhang et al. (2022) reported in Protein & Cell that FTO stabilizes MIS12 and counteracts senescence.

referenceOu B, Liu Y, Gao Z, Xu J, Yan Y, Li Y et al. reported in Cell Death & Disease (2022) that senescent neutrophil-derived exosomal piRNA-17560 promotes chemoresistance and epithelial-mesenchymal transition (EMT) in breast cancer via FTO-mediated m6A demethylation.

referenceSun et al. (2024) reported in the Journal of Inflammation Research that FTO stabilizes MIS12 to inhibit vascular smooth muscle cell senescence in atherosclerotic plaque.

claimThe m(6)A mRNA demethylase FTO regulates melanoma tumorigenicity and the response to anti-PD-1 blockade.

referenceJiang Z, Wang Y, Li Z, Dai Z, He Y, Chu K et al. reported in Cell Death & Disease (2021) that the m6A mRNA demethylase FTO in granulosa cells retards FOS-dependent ovarian aging.

claimThe FTO protein mediates LINE1 m(6)A demethylation and chromatin regulation in mouse embryonic stem cells (mESCs) and during mouse development.

referenceLi L, Yang L, Shen L, Zhao Y, Wang L, Zhang H reported in Reproductive Sciences (2024) that fat mass and obesity-associated protein (FTO) regulates granulosa cell aging by targeting the matrix metalloproteinase-2 gene via an N6-methyladenosine-YT521-B homology domain family member 2-dependent pathway in aged mice.