concept

fimbria-fornix lesion

Also known as: fimbria-fornix lesion, fimbria/fornix transection

Facts (10)

Sources

Rusty Gage, PhD - Salk Institute salk.edu Salk Institute 10 facts

referenceO.G. Nilsson, M.L. Shapiro, F.H. Gage, D.S. Olton, and A. Björklund published 'Spatial learning and memory following fimbria-fornix transection and grafting of fetal septal neurons to the hippocampus' in Experimental Brain Research in 1987.

referenceR.J. Mandel, Rusty Gage, D.G. Clevenger, S.K. Spratt, R.O. Snyder, and S.E. Leff demonstrated that nerve growth factor expressed in the medial septum via recombinant adeno-associated viral vector delivery protects cholinergic neurons from fimbria-fornix lesion-induced degeneration, as published in the 1999 Experimental Neurology.

referenceP.E. Batchelor, D.M. Armstrong, S.N. Blaker, and F.H. Gage observed the colocalization of nerve growth factor receptor and choline acetyltransferase in neurons within the rat forebrain following fimbria-fornix transection in a 1989 study published in the Journal of Comparative Neurology.

referenceH. Dickinson-Anson, I. Aubert, F.H. Gage, and L.J. Fisher authored the paper 'Hippocampal grafts of acetylcholine-producing cells are sufficient to improve behavioural performance following a unilateral fimbria-fornix lesion' published in Neuroscience in 1998 (Volume 84, Issue 3, pages 771-81).

referenceG.M. Peterson, L.R. Williams, S. Varon, and F.H. Gage published 'Loss of GABAergic neurons in medial septum after fimbria-fornix transection' in Neuroscience Letters in 1987.

referenceL.R. Williams, S. Varon, G.M. Peterson, K. Wictorin, W. Fischer, A. Bjorklund, and F.H. Gage found that continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection, as published in the Proceedings of the National Academy of Sciences in 1986.

referenceF.H. Gage, K. Wictorin, W. Fischer, L.R. Williams, S. Varon, and A. Bjorklund conducted a quantitative temporal analysis of retrograde cell changes in the medial septum and diagonal band following fimbria-fornix transection, as published in Neuroscience in 1986.

referenceF.H. Gage, A. Björklund, and U. Stenevi published 'Cells of origin of the ventral cholinergic septohippocampal pathway undergoing compensatory collateral sprouting following fimbria-fornix transection' in Neuroscience Letters in 1984.

referenceM.H. Tuszynski, D.M. Armstrong, and F.H. Gage reported in a 1990 Brain Research study that fimbria/fornix transection leads to basal forebrain cell loss.

referenceBlaker, S.N., Armstrong, D.M., and Gage, F.H. studied the response of cholinergic neurons within the rat hippocampus to fimbria-fornix transection.