Knowledge Tree
fibrosis
Facts (10)
Sources
Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 3 facts
claimIn chronic inflammation, infiltrating macrophages, lymphocytes, and plasma cells produce inflammatory cytokines, growth factors, and enzymes, which contribute to tissue damage progression and secondary repair processes such as fibrosis and granuloma formation.
claimChronic inflammation involves the production of inflammatory cytokines, growth factors, and enzymes, which contribute to tissue damage progression and secondary repair processes such as fibrosis and granuloma formation.
claimThe hallmarks of chronic inflammation include the infiltration of primary inflammatory cells—specifically macrophages, lymphocytes, and plasma cells—into the tissue site, where they produce inflammatory cytokines, growth factors, and enzymes that contribute to tissue damage and secondary repair processes like fibrosis and granuloma formation.
Homeostatic medicine: a strategy for exploring health and disease link.springer.com Sep 26, 2022 2 facts
claimLong-term constriction or dilation of blood vessels can lead to excessive dilation, thinning, aneurysm, or arterial rupture, while excessive fibrosis of blood vessels leads to vascular sclerosis and hemadostenosis.
claimIn rats with xerostomia caused by ovariectomy, inorganic nitrate upregulated the expression of aquaporin-5 in the salivary glands, which increased salivary secretion and reduced fibrosis and acinous atrophy of salivary gland tissues, according to Xu et al. (2018).
The Center for Inflammation Science and Systems Medicine wertheim.scripps.ufl.edu 1 fact
claimThe body's response to persistent inflammation in a specific organ is the development of scar tissue or fibrosis, which can occur in the heart, lung, liver, kidneys, or bowel and reduce organ function.
Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com 1 fact
claimIn the context of viral lung infections, resident macrophages phagocytose apoptotic cells and subsequently release pro-inflammatory cytokines, which recruit other immune cells, cause acute inflammation, and provoke fever and fibrosis.
The Role of Immune Cells in Inflammation jmolpat.com 1 fact
claimChronic inflammation is characterized by the sustained production of pro-inflammatory cytokines and the persistent recruitment of immune cells to the affected tissue, leading to tissue damage, fibrosis, and impaired tissue function.
Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 1 fact
claimEndothelial dysfunction leads to structural and functional heart problems, including hypertrophy, dilation, diastolic and systolic dysfunction, fibrosis, lowered exercise tolerance, and extracellular matrix dysregulation.
The New Field of Network Physiology: Building the Human ... frontiersin.org 1 fact
referenceThe study 'An Analytic Model of Tissue Self-Healing and its Network Implementation: Application to Fibrosis and Aging' (Front. Physiol. 11, 1338) presents an analytic model for tissue self-healing and its application to fibrosis and aging.