concept

Fibroblast growth factor-2

Also known as: FGF-2, Fgf-2

Facts (12)

Sources

Rusty Gage, PhD - Salk Institute salk.edu Salk Institute 12 facts

referenceFibroblast growth factor-2 activates a latent neurogenic program in neural stem cells derived from diverse regions of the adult central nervous system, according to T.D. Palmer, E.A. Markakis, A.R. Willhoite, F. Safar, and F.H. Gage in a 1999 Journal of Neuroscience publication.

claimA 10-amino acid sequence of fibroblast growth factor 2 is sufficient to induce mitogenic activity on neural progenitor cells, as reported by Ray, Baird, and Gage in 1997.

referencePhilippe Taupin, J. Ray, W.H. Fischer, S.T. Suhr, K. Hakansson, A. Grubb, and Rusty Gage published 'FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor' in Neuron in 2000.

claimEpidermal growth factor and fibroblast growth factor-2 exert different effects on neural progenitors in the adult rat brain, according to Kuhn, Winkler, Kempermann, Thal, and Gage in 1997.

referenceFGF-2-responsive neuronal progenitors are present in both proliferative and quiescent regions of the adult rodent brain, as reported in a 1995 study in Molecular and Cellular Neurosciences.

referenceThe storage, metabolism, and processing of 125I-fibroblast growth factor-2 after intracerebral injection were studied by A.M. Gonzalez, L.S. Carman, M. Ong, J. Ray, F.H. Gage, C.W. Shults, and A. Baird in 1994.

referenceC.W. Shults, J. Ray, K. Tsuboi, and Rusty Gage published 'Fibroblast growth factor-2-producing fibroblasts protect the nigrostriatal dopaminergic system from 6-hydroxydopamine' in Brain Research in 2000.

referenceMinger, S.L., Fisher, L.J., Ray, J., and Gage, F.H. reported the long-term survival of transplanted basal forebrain cells following in vitro propagation with fibroblast growth factor-2 in a 1996 study.

referenceFagan, A.M., Suhr, S.T., Lucidi-Phillipi, C.A., Peterson, D.A., Holtzman, D.M., and Gage, F.H. reported in a 1997 Journal of Neuroscience paper that endogenous fibroblast growth factor-2 (FGF-2) is important for cholinergic sprouting in the denervated hippocampus.

referenceFibroblast growth factor-2 protects entorhinal layer II glutamatergic neurons from axotomy-induced death, according to a 1996 study published in the Journal of Neuroscience.

claimFibroblast growth factor-2 (FGF-2) is sufficient to isolate progenitor cells found in the adult mammalian spinal cord, according to Shihabuddin, Ray, and Gage in 1997.

referenceT. Ueba, B. Kaspar, X. Zhao, and Rusty Gage identified that a novel transcription factor represses human fibroblast growth factor 2, as published in the 1999 Journal of Biological Chemistry.