Knowledge Tree
fibroblast
Also known as: fibroblast, fibroblasts
Facts (23)
Sources
Healthy vs. Infected Wounds: A Clinician's Guide - Net Health nethealth.com Jun 24, 2025 5 facts
claimPersistent inflammation in infected wounds leads to an increased release of pro-inflammatory cytokines that can damage healthy tissue, excessive redness and swelling that hinders nutrient and oxygen delivery, and impaired migration of fibroblasts and other cells essential for tissue repair.
claimHemostasis is the immediate phase of wound healing where platelets aggregate at the injury site to form a clot, acting as a temporary barrier to prevent blood loss, and eventually releasing growth factors and fibroblasts to initiate collagen production.
claimThe inflammation phase of wound healing occurs between 1 and 6 days post-injury and is characterized by the influx of immune cells, starting with neutrophils clearing debris and bacteria, followed by macrophages that remove debris and release growth factors to stimulate fibroblast and endothelial cell activity.
claimThe proliferation phase of wound healing occurs between 6 and 21 days post-injury and involves fibroblasts migrating to the wound site to synthesize collagen, the formation of new blood vessels, epithelial cell migration to cover the wound surface, and myofibroblast contraction to reduce wound size.
claimInfection impairs the proliferation phase of wound healing by damaging fibroblasts with inflammatory mediators, which reduces collagen synthesis and the formation of healthy granulation tissue.
Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com 5 facts
claimIL-6 is produced by monocytes, fibroblasts, and endothelial cells, and upon stimulation, it is secreted by macrophages, T cells, B cells, mast cells, glial cells, eosinophils, keratinocytes, and granulocytes.
claimMacrophage colony-stimulating factor (M-CSF) is involved in adaptive immunity, produced by fibroblasts and endothelium, and binds to CD115 on stem cells to promote monocyte production and activation.
referenceIL-6 is classified as a pro-inflammatory cytokine, is produced by Th cells, macrophages, and fibroblasts, binds to CD126 and CD130 receptors, targets B cells and plasma cells, and functions in B-cell differentiation.
claimInterferon-beta (IFN-β) is a pro-inflammatory cytokine produced by fibroblasts that binds to CD118 (IFNAR1, IFNAR2) and functions as an anti-viral and anti-proliferative agent.
referenceGM-CSF is classified as an adaptive immunity cytokine, is produced by T cells, macrophages, and fibroblasts, binds to CD116 and CDw131 receptors, targets stem cells, and functions in the growth and differentiation of monocytes and the production of eosinophils and granulocytes.
Wound Healing Phases - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 3 facts
claimDuring the inflammatory phase of wound healing, inflammatory cells release mediators and cytokines that promote angiogenesis, thrombosis, and reepithelialization, while fibroblasts lay down extracellular components to serve as scaffolding.
claimBy days 5 through 7 of the wound healing process, fibroblasts begin to deposit new collagen and glycosaminoglycans, which form the core of the wound and help stabilize it.
claimPlatelet-derived growth factor attracts fibroblasts and, in conjunction with transforming growth factor, enhances the division and multiplication of fibroblasts, which then synthesize collagen.
Wound Inflammation lakecountyin.gov 2 facts
claimDuring the resolution phase of inflammation, fibroblasts and other cells initiate tissue regeneration and collagen deposition to repair the wound.
claimDuring the resolution phase of wound healing, anti-inflammatory signals are activated, and fibroblasts begin the process of tissue regeneration and collagen deposition.
Understanding the Stages of Wound Healing healogics.com 2 facts
claimThe wound healing process involves angiogenesis, where new blood vessels form to support fibroblasts engaged in fibroplasia, creating granulation tissue that serves as a foundation for epithelial cell migration.
claimFibroplasia is the process where fibroblasts produce collagen and extracellular matrix to synthesize the structural framework for new tissue.
What are Cytokines? Types & Function - Cleveland Clinic my.clevelandclinic.org Jan 3, 2023 1 fact
claimNon-immune cells that release cytokines include endothelial cells (lining blood vessels), epithelial cells (lining organs), fibroblasts (connective tissue), stromal cells (connective tissue), and Schwann cells (surrounding neurons).
Understanding the Inflammatory and Healing Process - Myo-Fit myofittherapy.com Nov 12, 2024 1 fact
procedureThe proliferation phase of healing involves the activation of fibroblasts, which produce collagen to lay down new connective tissue to replace damaged or destroyed tissue.
Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 1 fact
claimNonspecific proliferative chronic inflammation is characterized by the presence of non-specific granulation tissue formed by the infiltration of mononuclear cells, such as lymphocytes, macrophages, and plasma cells, alongside the proliferation of fibroblasts, connective tissue, vessels, and epithelial cells, as seen in nasal or cervical polyps and lung abscesses.
The 4 Stages of Wound Healing and Your Role in the Process essentiahealth.org Aug 27, 2025 1 fact
claimThe proliferation stage of wound healing produces new, healthy tissue to cover the wound and restore natural look and function, characterized by skin cells spreading to form a protective barrier and fibroblasts multiplying to aid in collagen production.
The Four Stages of Wound Healing woundevolution.com 1 fact
claimKeloid and hypertrophic scarring are caused by excessive collagen production and cell buildup, resulting from fibroblasts and keratinocytes working harder than necessary to rebuild damaged tissues.
Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us 1 fact
measurementWounds treated with 0.2% silybin gel showed more collagen fibers, fibroblasts, and proliferating blood capillaries, according to Hu et al. [104].