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fatty acid oxidation
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Dietary interventions as regulators of stem cell behavior in ... genesdev.cshlp.org 7 facts
claimBoth a high-fat diet and intermittent fasting lead to intestinal stem cell-autonomous activation of PPARδ signaling, which enhances self-renewal through partial activation of a Wnt signaling program and enhanced fatty acid oxidation.
claimFasting increases PPAR-dependent fatty acid oxidation in intestinal stem cells (ISCs) to maintain stemness, according to Mihaylova et al. (2018).
claimCirculating lipid availability increases under conditions of caloric restriction, the ketogenic diet, and Western diets, and the accompanying increased fatty acid oxidation provides insights into the convergence of phenotypes observed with these diets, as noted by Corton et al. (2004), Sikder et al. (2018), Steinhauser et al. (2018), and Rosenbaum et al. (2019).
claimNeural stem/progenitor cells increase fatty acid oxidation during periods of quiescence and increase fatty acid synthesis after stem cell activation and during proliferative periods, as reported by Knobloch et al. (2013, 2017).
referenceBlocking glucose oxidation in the tricarboxylic acid (TCA) cycle triggers compensatory oxidation of other substrates, including fatty acids (FAs), which may link decreased glucose availability to enhanced fatty acid oxidation in stem cells during dietary interventions (Corton et al. 2004; Sikder et al. 2018; Steinhauser et al. 2018; Rosenbaum et al. 2019).
claimGenetic inhibition of glucose oxidation enhances intestinal stem cell (ISC) self-renewal, serving as an orthogonal method to enhance ISC fatty acid oxidation, as reported by Bensard et al. (2020).
claimTumor-initiating cells in squamous cell carcinoma normally up-regulate the fatty acid transporter CD36, suggesting that the uptake and oxidation of fatty acids are partially responsible for the increased metastasis observed after a high-fat diet.
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 2 facts
claimMetabolic reprogramming, characterized by increased glycolysis, upregulated glutaminolysis, and accelerated fatty acid oxidation, is a key contributor to fibrosis.
claimTargeted inhibition of metabolic processes such as glycolysis, glutaminolysis, and fatty acid oxidation can regulate collagen production, reduce extracellular matrix (ECM) accumulation, and alleviate the progression of fibrosis.
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 1 fact
referenceTimper, K., Del Río-Martín, A., Cremer, A.L., Bremser, S., Alber, J., Giavalisco, P., et al. (2020) found that GLP-1 receptor signaling in astrocytes regulates fatty acid oxidation, mitochondrial integrity, and function, published in Cell Metabolism.