concept

extracellular vesicles

Also known as: EVs, circulating extracellular vesicles

Facts (14)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 10 facts

referenceYin et al. (2021) investigated the roles of extracellular vesicles in the aging microenvironment and age-related diseases.

claimStrategies for tissue regeneration include the elimination of senescent cells with senolytics, exogenous stem cell transplantation to replenish the stem cell pool, the use of extracellular vesicles (EVs) and their engineered derivatives to alleviate cellular senescence, and the application of wound inflammatory and chemical compounds to rejuvenate stem cells.

referenceLehallier et al. (2022) found that the rejuvenation of neutrophils and their extracellular vesicles is associated with enhanced aged fracture healing.

claimStrategies for restoring a youthful skin state include using stem cells and related extracellular vesicles (EVs), pharmacological activation of autophagy, maintaining circadian rhythmicity in skin-resident stem cells, and regulating metabolic homeostasis to restore mitochondrial integrity and metabolic output.

claimExtracellular vesicles secreted by neonatal mesenchymal stem cells (MSCs) can deposit proliferating cell nuclear antigen (PCNA) to reverse aged bone marrow mesenchymal stem cells (BMSCs) and slow age-related degeneration.

claimExtracellular signaling molecules, including extracellular vesicles (EVs), neurotransmitters, growth factors, hormones, and cytokines, function as cues to transmit information to target somatic cells or adult stem cells.

claimExtracellular vesicles (EVs) function as a tool for stem cell rejuvenation due to their ability to transfer genes safely and produce systemic effects.

referenceMehdipour et al. (2021) demonstrated the regulation of aged skeletal muscle regeneration by circulating extracellular vesicles.

referencePicca et al. (2019) analyzed extracellular vesicles to gain insights into mitochondrial dysfunction and aging.

referenceMonti et al. (2021) explored whether extracellular vesicles serve as footprints of environmental exposures in the aging process.

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 3 facts

referenceThe article 'Extracellular vesicles from stem and progenitor cells for cell-free regenerative therapy' was published in Current Molecular Medicine in 2022 (Volume 22, pages 120–31).

referenceFang J, Chen Z, Lai X, Yin W, Guo Y, Zhang W et al. reported in Bioorganic Chemistry (2022) that mesenchymal stem cell-derived HIF-1α-overexpressed extracellular vesicles ameliorate hypoxia-induced pancreatic β cell apoptosis and senescence through activating YTHDF1-mediated protective autophagy.

referenceThe article 'Mesenchymal stem cell-derived exosomes and other extracellular vesicles as new remedies in the therapy of inflammatory diseases' was published in Cells in 2019 (Volume 8).

Antiageing strategy for neurodegenerative diseases - Nature nature.com Nature Mar 10, 2025 1 fact

claimExtracellular vesicles deposit PCNA to rejuvenate aged bone marrow-derived mesenchymal stem cells and slow age-related degeneration, as reported by Lei et al. in Science Translational Medicine (2021).