Knowledge Tree
epidermal stem cells
Also known as: EpSCs, epidermal stem cell
Facts (10)
Sources
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 6 facts
claimAged epidermal cells have the ability to dedifferentiate into epidermal stem cells (EpSCs) through the activation of the Wnt/β-catenin pathway.
claimCOL17A1 plays a role in epidermal stem cell (EpSC) competition to orchestrate skin homeostasis and aging, and COL17A1 overexpression helps combat skin aging.
claimThe dedifferentiation of aged epidermal cells into epidermal stem cells (EpSCs) offers potential for reversing skin aging and promoting wound repair.
claimHuang et al. (2020) identified that Lgr6 marks epidermal stem cells which play a nerve-dependent role in wound re-epithelialization.
claimFu et al. demonstrated that dedifferentiation-derived cells cultivated in vitro share phenotypic and functional traits with epidermal stem cells (EpSCs).
claimWang et al. (2022) demonstrated that exosomes derived from epidermal stem cells improve diabetic wound healing.
Dietary interventions as regulators of stem cell behavior in ... genesdev.cshlp.org 4 facts
referenceBlocking glucose entry into the tricarboxylic acid (TCA) cycle in epidermal stem cells promotes their differentiation (Goguet-Rubio et al. 2016; Baksh et al. 2020).
claimIn response to inflammation, both epidermal stem cells and hematopoietic stem cells (HSCs) activate cholesterol biosynthesis genes and maintain them in a chromatin-poised state, allowing for more rapid activation upon subsequent inflammatory encounters, as reported by Naik et al.
claimInflammatory memory in epidermal stem cells enhances their ability to heal wounds.
claimAlpha-ketoglutarate (αKG) accumulation acts as a prodifferentiation factor in several tissue types, including premalignant epidermal stem cells, intestinal stem cells, and pancreatic cancer cells.