Knowledge Tree
endothelial cells
Also known as: vascular endothelial cells, endothelial cell
Facts (16)
Sources
Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com 6 facts
claimTNF-α plays a role in the inflammatory response locally and in circulation, triggers the expression of vascular endothelial cells, and enhances leukocyte adhesion molecules to stimulate immune cell infiltration.
procedureMacrophages and endothelial cells produce large amounts of IL-6 after activation, which activates T cells and other immune cells, creating a positive feedback loop that results in a cytokine storm, the release of additional cytokines and chemokines, and the upregulation of acute phase proteins.
claimIL-6 is produced by monocytes, fibroblasts, and endothelial cells, and upon stimulation, it is secreted by macrophages, T cells, B cells, mast cells, glial cells, eosinophils, keratinocytes, and granulocytes.
claimActivated macrophages, dendritic cells, other immune cells, and endothelial cells release pro-inflammatory cytokines.
claimThe release of IFN-γ or TNF-α during a cytokine storm leads to the activation of macrophages, dendritic cells, other immune cells, and endothelial cells.
procedureIn the pathogenesis of a cytokine storm, the activation of T cells or the lysis of immune cells induces the release of IFN-γ or TNF-α, which subsequently activates macrophages, dendritic cells, other immune cells, and endothelial cells.
Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 3 facts
claimThe cytokines IL-1 and TNF-α induce injury-site endothelial cells to release Selectins and Integrins, which stimulate chemotaxis and diapedesis of circulating leukocytes.
claimCytokines released by macrophages and dendritic cells (such as IL-1 and TNF-α) induce endothelial cells at the injury site to release Selectins and Integrins, which stimulate the chemotaxis and diapedesis of circulating leukocytes.
claimIn response to foreign or self-antigens, tissue immune cells like macrophages and dendritic cells release cytokines such as IL-1 and TNF-α, which induce endothelial cells at the injury site to release Selectins and Integrins to stimulate leukocyte chemotaxis and diapedesis.
Medicinal plants: bioactive compounds, biological activities ... frontiersin.org 1 fact
claimCandida albicans virulence factors bind to endothelial cells in blood vessels and epithelial cells in the respiratory tract, influencing pseudo-hyphae development.
What are Cytokines? Types & Function - Cleveland Clinic my.clevelandclinic.org Jan 3, 2023 1 fact
claimNon-immune cells that release cytokines include endothelial cells (lining blood vessels), epithelial cells (lining organs), fibroblasts (connective tissue), stromal cells (connective tissue), and Schwann cells (surrounding neurons).
The Good, The Bad and the Ugly of Inflammation medschool.vanderbilt.edu Feb 10, 2015 1 fact
claimSepsis causes endothelial cells lining blood vessels to leak, which disrupts circulation and can lead to acute septic shock, multiple organ failure, and rapid death.
Healthy vs. Infected Wounds: A Clinician's Guide - Net Health nethealth.com Jun 24, 2025 1 fact
claimThe inflammation phase of wound healing occurs between 1 and 6 days post-injury and is characterized by the influx of immune cells, starting with neutrophils clearing debris and bacteria, followed by macrophages that remove debris and release growth factors to stimulate fibroblast and endothelial cell activity.
Wound Healing Phases - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 1 fact
claimInflammatory cells, including neutrophils, monocytes, and endothelial cells, adhere to a fibrin scaffold formed by platelet activation.
Understanding the Stages of Wound Healing healogics.com 1 fact
claimAngiogenesis is the process of forming new blood vessels where endothelial cells from nearby vessels migrate into the wound site to form new capillaries, which supply oxygen and nutrients to new tissue.
The Role of Immune Cells in Inflammation jmolpat.com 1 fact
claimTumor Necrosis Factor-alpha (TNF-α) is a key cytokine produced during inflammation that activates endothelial cells lining blood vessels, leading to increased vascular permeability and the recruitment of additional immune cells to the site of inflammation.