concept

dorsolateral prefrontal cortex

Also known as: DLPFC, PFC, right dorsolateral prefrontal cortex

Facts (19)

Sources

Self-awareness, self-regulation, and self-transcendence (S-ART) frontiersin.org Frontiers in Human Neuroscience 17 facts

claimNovices exhibit strong functional coupling between the right posterior insular cortex (PIC) and the medial prefrontal cortex (mPFC), whereas meditators show more significant connectivity between the right posterior insular cortex (PIC) and the dorsolateral prefrontal cortex (DLPFC).

claimStudies using the posterior cingulate cortex (PCC) as a seed have found increased connectivity with the dorsal anterior cingulate cortex (dACC) and the dorsolateral prefrontal cortex (DLPFC) at rest, and increased connectivity with the dorsal ACC during meditation.

claimManna and colleagues (2010) observed that right dorsolateral prefrontal cortex (DLPFC) deactivation was positively correlated with meditation expertise, suggesting that advanced practitioners exert less effort during focused attention (FA) meditation.

claimMeditators using an experiential first-person perspective (FPP) focus toward valenced trait descriptive words exhibit a shift in neural activity away from midline cortices toward a right lateralized network consisting of the ventrolateral prefrontal cortex (VLPFC) and dorsolateral prefrontal cortex (DLPFC), compared to those using an evaluative focus.

claimBilateral ventral lateral prefrontal cortex (VLPFC) likely plays roles in both non-conscious and conscious processing, with right VLPFC activity specifically associated with conscious forms of specialization such as response inhibition, and integrated roles with the dorsolateral prefrontal cortex (DLPFC), motor areas, and the medial temporal lobe.

referenceDavidson and Irwin (1999) delineated functional differences between the ventromedial and dorsolateral sectors of the prefrontal cortex (PFC), suggesting that activation of the ventromedial PFC represents immediate valenced goal states along with activation of the ventral striatopallidum (including the nucleus accumbens), while the dorsolateral PFC represents valenced goal states in the absence of immediately present incentives.

referenceThe fronto-parietal control system (FPCS) consists of the rostral frontopolar prefrontal cortex (FPC), right ventrolateral prefrontal cortex (VLPFC), dorsomedial prefrontal cortex (DMPFC), dorsal anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), anterior insular cortex (AIC), lateral cerebellum, and anterior inferior parietal lobe (aIPL).

claimThe right DLPFC, dorsal ACC, and the temporo-parietal junction (TPJ) are associated with modulating and maintaining response readiness in preparation for an impending stimulus.

referenceThe right dorsolateral prefrontal cortex (DLPFC) is implicated in the extinction of aversive associations, while the right ventrolateral prefrontal cortex (VLPFC) is implicated in non-aversive extinction recall, as reported by Morgan and Ledoux (1999).

claimThe dorsolateral prefrontal cortex (DLPFC), the anterior cingulate cortex (ACC), and the insula are the three most widely cited brain areas showing activity and gross morphological change during and in response to Focused Attention (FA) and Open Monitoring (OM) meditation training.

claimThe right dorsolateral prefrontal cortex (DLPFC) and dorsal anterior cingulate cortex (ACC) are thought to act in an executive capacity, potentially responsible for vigilance, alertness, monitoring performance, and regulating arousal levels.

claimThe anterior inferior parietal lobe (aIPL) and dorsolateral prefrontal cortex (DLPFC) are implicated in working memory and are thought to contribute to regulating attention within the fronto-parietal control system.

claimThe dorsolateral prefrontal cortex (DLPFC) may contribute to a sustained form of motivation that remains in working memory during meditation practice.

referenceSubdivisions of the prefrontal cortex (PFC) implicated in emotion and cognitive control processes, including decision-making, appraisal, and impulse control, include the orbitofrontal cortex (OFC), dorsomedial prefrontal cortex (DMPFC), anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), and ventrolateral prefrontal cortex (VLPFC).

claimThe Frontoparietal Control System (FPCS) has functional overlap with the Experiential Self-specifying (EPS) network, which includes the dorsolateral prefrontal cortex (DLPFC), dorsomedial prefrontal cortex (DMPFC), and anterior insular cortex (AIC).

claimA study by Lazar et al. (2005) of Vipassana practitioners with over 2,500 hours of practice found increased cortical thickness in the anterior insular cortex (AIC), dorsolateral prefrontal cortex (DLPFC), anterior prefrontal cortex (PFC), and sensory cortices.

referenceStructural connectivity between the dorsolateral prefrontal cortex (DLPFC) and the amygdala is implicated in learned safety, suggesting effortful control over the expression of fear-related behavior, as reported by Pollak et al. (2010).

Neuroimaging in psychedelic drug development: past, present, and ... nature.com Nature Sep 27, 2023 2 facts

referenceLoheswaran G, Barr MS, Zomorrodi R, Rajji TK, Blumberger DM, Foll BL, et al. authored 'Impairment of Neuroplasticity in the Dorsolateral Prefrontal Cortex by Alcohol', published in Scientific Reports in 2017, volume 7, page 1.

referenceSalavati B, Daskalakis ZJ, Zomorrodi R, Blumberger DM, Chen R, Pollock BG, et al. authored 'Pharmacological modulation of long-term potentiation-like activity in the dorsolateral prefrontal cortex', published in Frontiers in Human Neuroscience in 2018, volume 12, page 155.