concept

dopaminergic neurons

Also known as: human dopaminergic neurons, dopaminergic cells, dopamine neurons

Facts (8)

Sources

Extent and Health Consequences of Chronic Sleep Loss and ... - NCBI ncbi.nlm.nih.gov Colten HR, Altevogt BM · National Academies Press 4 facts

claimNeurodegeneration in Parkinson's disease involves a reduction in the number of dopaminergic neurons in the substantia nigra, noradrenergic neurons in the locus coeruleus, and cholinergic neurons in the pedunculopontine nucleus.

measurementIn patients with neurodegenerative conditions, dopaminergic neurons in the substantia nigra and noradrenergic neurons in the locus coeruleus are dramatically reduced in number (Jellinger, 1986).

claimDopaminergic neurons in the substantia nigra, noradrenergic neurons in the locus coeruleus, and cholinergic neurons in the pedunculopontine nucleus are reduced in number in neurodegenerative conditions.

claimDopaminergic neurons in the substantia nigra are dramatically reduced in number, as are noradrenergic neurons in the locus coeruleus (Jellinger, 1986) and cholinergic neurons in the pedunculopontine nucleus (Zweig et al., 1989).

Rusty Gage, PhD - Salk Institute salk.edu Salk Institute 2 facts

referenceC.W. Shults, R. Hashimoto, R.M. Brady, and F.H. Gage observed in a 1990 Neuroscience study that dopaminergic cells align along radial glia in the developing mesencephalon of the rat.

referenceBrundin, P., Strecker, R.E., Gage, F.H., Lindvall, O., and Björklund, A. investigated the intracerebral transplantation of dopamine neurons to understand the functional role of the mesolimbocortical dopamine system and to develop a therapy for Parkinson's disease.

Integrating allostasis and emerging technologies to study complex ... nature.com Nature Nov 5, 2025 1 fact

referenceCavalleri, L. et al. published 'Cortisol-dependent impairment of dendrite plasticity in human dopaminergic neurons derived from hiPSCs is restored by ketamine: Relevance for major depressive disorders' in the journal Neuroscience Applied in 2024.

Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Springer Dec 19, 2024 1 fact

claim2R,6R-hydroxynorketamine (2R,6R-HNK) enhances structural plasticity in dopaminergic neurons through AMPAR-driven BDNF and mTOR signaling pathways.