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corticotropin-releasing hormone
Also known as: CRF, corticotrophin-releasing hormone, corticotropin-releasing factor, corticotrophin-releasing factor, corticotropin-releasing hormone
Facts (11)
Sources
Systems and organs | Anatomy and Physiology | Research Starters ebsco.com 4 facts
claimCortisol secretion is regulated by a complex feedback system where stress triggers the hypothalamus to release corticotropin-releasing factor (CRF), which stimulates the pituitary to release adrenocorticotropic hormone (ACTH), which in turn stimulates the adrenal glands to secrete cortisol.
claimHigh levels of cortisol inhibit the secretion of corticotropin-releasing factor (CRF) and adrenocorticotropic hormone (ACTH).
claimHigh levels of adrenocorticotropic hormone (ACTH) inhibit the secretion of corticotropin-releasing factor (CRF), which is the hormone that triggers ACTH secretion.
claimCorticotropin-releasing factor (CRF) provides feedback to the hypothalamus, its organ of origin, to halt its own secretion.
Allostasis revisited: A perception, variation, and risk framework frontiersin.org Sep 28, 2022 3 facts
claimThe primary activation of glucocorticoid signaling is generally agreed to commence at the hypothalamus via the neuroendocrine secretion of corticotropin-releasing factor (CRF), according to Sapolsky et al. (2000), Romero and Wingfield (2016), and Blas and Fairhurst (2022).
claimPotential mechanisms for the physiological overload threshold include critical occupancy of certain receptors, a ratio of occupancy of different receptors, accumulation of products over time, displacement of other steroids from their ligands, or actions of peptides elsewhere in the HPA cascade such as corticotropin-releasing factor (CRF) or adrenocorticotropin hormone (ACTH).
claimPotential mechanisms for the 'overload' threshold include critical occupancy of certain receptors, the ratio of occupancy of different receptors, the accumulation of products over time, or factors independent of receptor binding such as steroid displacement or the actions of peptides like corticotropin-releasing factor (CRF) or adrenocorticotropin hormone (ACTH).
Understanding Allostasis: Stability Through Change - Cannelevate cannelevate.com.au Jan 2, 2026 1 fact
claimNeuroendocrine markers used to measure allostatic load include cortisol, dehydroepiandrosterone sulphate (DHEA-S), corticotropin-releasing hormone (CRH), epinephrine, and norepinephrine.
Stress, Lifestyle, and Health – Psychology 2e OpenStax pressbooks.cuny.edu 1 fact
procedureIn response to stress, the hypothalamus releases corticotrophin-releasing factor, which causes the pituitary gland to release adrenocorticotropic hormone (ACTH). ACTH then activates the adrenal glands to secrete hormones, including cortisol, into the bloodstream.
Physiology, Male Reproductive System - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 1 fact
claimThe hypothalamus releases corticotrophin-releasing hormone (CRH), which stimulates the anterior pituitary to release adrenocorticotropic hormone (ACTH).
Stress, Lifestyle, and Health – Introduction to Psychology open.maricopa.edu 1 fact
claimIn response to stress, the hypothalamus releases corticotrophin-releasing factor, which stimulates the pituitary gland to release adrenocorticotropic hormone (ACTH).