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corpus luteum
Also known as: human corpus luteum, corpora lutea
Facts (72)
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The Normal Menstrual Cycle and the Control of Ovulation - NCBI - NIH ncbi.nlm.nih.gov Aug 5, 2018 39 facts
claimAdministration of Luteinizing hormone (LH) or Human Chorionic Gonadotropin (HCG) during the luteal phase can extend corpus luteum function for an additional two weeks.
claimLarge cells in the corpus luteum are more active in steroidogenesis and are influenced by autocrine/paracrine factors including inhibin, relaxin, and oxytocin.
claimThe corpus luteum is a transient endocrine organ that primarily secretes progesterone to prepare the estrogen-primed endometrium for implantation of the fertilized ovum.
claimThe corpus luteum can accumulate blood in its central cavity, becoming a hemorrhagic corpus luteum.
claimEstrogen is believed to play a role in the luteolysis of the corpus luteum.
claimIn response to angiogenic factors secreted by granulosa and thecal cells, the basal lamina of the corpus luteum dissolves and capillaries invade the granulosa layer.
claimDuring the last few days of the menstrual cycle, declining steroid production by the corpus luteum and a dramatic fall of inhibin A allow follicle stimulating hormone (FSH) levels to rise.
claimCorpus luteum function begins to decline 9-11 days after ovulation.
claimThe corpus luteum and its control mechanisms have been studied in infraprimate species, according to a 1994 chapter by Niswender and Nett in The Physiology of Reproduction.
claimThe human corpus luteum secretes relaxin, oxytocin, and progesterone, according to a 1989 study by Khan-Dawood et al. published in the Journal of Clinical Endocrinology & Metabolism.
claimEstradiol injected into the ovary bearing the corpus luteum induces luteolysis, while no effect is noted after estradiol injection of the contralateral ovary.
claimThe corpus luteum consists of at least two cell types: large cells, which are derived from granulosa cells, and small cells, which are thought to be derived from thecal cells.
claimThe absence of estrogen receptors in human luteal cells suggests that endogenous estrogen does not play a role in corpus luteum regression.
measurementPeak vascularization of the corpus luteum is achieved eight or nine days after ovulation, which corresponds to the time of expected implantation and peak serum levels of progesterone and estradiol.
claimThe life span of the corpus luteum depends on continued luteinizing hormone (LH) support.
claimThe corpus luteum's life span depends on continued luteinizing hormone (LH) support, and its function declines by the end of the luteal phase unless human chorionic gonadotropin is produced by a pregnancy.
claimThe life span of the corpus luteum can be reduced by continuous Luteinizing hormone (LH) administration during the follicular or luteal phase, reduced LH concentration, decreased LH pulse frequency, or decreased LH pulse amplitude.
claimOvarian vein studies confirm that the corpus luteum is the site of steroid production during the luteal phase of the menstrual cycle.
claimBasal vacuolization at the base of endometrial cells in a formalin-fixed specimen confirms the formation of a functional, progesterone-producing corpus luteum.
claimOvarian vein studies confirm that the corpus luteum is the site of steroid production during the luteal phase.
claimAfter ovulation, remaining granulosa cells enlarge, become vacuolated, and accumulate a yellow pigment called lutein, combining with theca-lutein cells and stroma to form the corpus luteum.
claimThe number of granulosa cells formed during the follicular phase and the amount of readily available LDL cholesterol may play a role in steroid regulation by the corpus luteum.
measurementPeak vascularization of the corpus luteum is achieved approximately eight or nine days after ovulation, which corresponds to the time of expected implantation and peak serum levels of progesterone and estradiol.
claimAdministration of LH or HCG during the luteal phase can extend corpus luteum function for an additional two weeks.
claimThe life span of the corpus luteum can be reduced by continuous LH administration, reduced LH concentration, decreased LH pulse frequency, or decreased LH pulse amplitude.
claimReduced levels of FSH during the follicular phase can lead to a shortened luteal phase and the development of a smaller corpus luteum.
claimDuring the last few days of the menstrual cycle, follicle stimulating hormone (FSH) levels rise due to declining steroid production by the corpus luteum and a dramatic fall in inhibin A levels.
claimProgesterone secretion in the human corpus luteum is pulsatile, as evidenced by a 1984 study by Filicori, Butler, and Crowley published in the Journal of Clinical Investigation.
claimThe corpus luteum is a transient endocrine organ that primarily secretes progesterone to prepare the estrogen-primed endometrium for implantation of the fertilized ovum.
claimIf the corpus luteum is not rescued by pregnancy, it undergoes atresia, and the resulting progesterone withdrawal causes menses.
claimIf pregnancy does not occur, the corpus luteum undergoes luteolysis under the influence of estradiol and prostaglandins and forms scar tissue called the corpus albicans.
claimMechanisms controlling corpus luteum function, particularly regarding the timing of luteolysis, have been studied in sheep, cows, nonhuman primates, and women, according to a 1988 review by Auletta and Flint published in Endocrine Reviews.
claimThe basal lamina dissolves and capillaries invade the granulosa layer of the corpus luteum in response to angiogenic factors secreted by granulosa and thecal cells.
claimIn the absence of pregnancy, steroid hormone levels fall due to declining corpus luteum function, and progesterone withdrawal results in increased coiling and constriction of the spiral arterioles, leading to menstruation.
claimReduced levels of Follicle-Stimulating Hormone (FSH) during the follicular phase can lead to a shortened luteal phase and the development of a smaller corpus luteum.
claimBaboon corpus luteum oxytocin acts as an intragonadal peptide modulator of luteal function, according to a 1988 study in the American Journal of Obstetrics and Gynecology.
claimThe corpus luteum is subject to endocrine regulation, according to a 1988 review by Keyes and Wiltbank published in the Annual Review of Physiology.
claimIf pregnancy does not occur, the corpus luteum undergoes luteolysis under the influence of estradiol and prostaglandins, forming scar tissue known as the corpus albicans.
claimThe absence of estrogen receptors in human luteal cells suggests that endogenous estrogen does not play a role in corpus luteum regression.
Unknown source 7 facts
claimThe mechanism by which the corpus luteum regulates steroid secretion is not completely understood, though it may be determined in part by LH secretory patterns, LH receptors, or variations in the levels of enzymes regulating steroid hormone production, such as 3β-HSD, CYP17, CYP19, or side chain cleavage enzyme.
referenceP.L. Keyes and M.C. Wiltbank published 'Endocrine regulation of the corpus luteum' in the Annual Review of Physiology in 1988.
referenceM. Filicori, J.P. Butler, and W.F. Crowley Jr. published 'Neuroendocrine regulation of the corpus luteum in the human. Evidence for pulsatile progesterone secretion' in the Journal of Clinical Investigation in 1984.
referenceI.D. Cooke published 'The corpus luteum' in Human Reproduction in 1988.
claimCorpus luteum function declines by the end of the luteal phase unless human chorionic gonadotropin (hCG) is produced due to pregnancy.
imageFigure 8 demonstrates a corpus luteum as seen on transvaginal ultrasound, showing increased blood flow surrounding the structure as seen with Doppler evaluation.
claimThe corpus luteum is formed by the combination of luteinized granulosa cells, newly formed theca-lutein cells, and surrounding ovarian stroma.
The Menstrual Cycle | Patient Education - UCSF Health ucsfhealth.org 5 facts
claimThe corpus luteum is formed from cells in the ovarian follicle that remain after ovulation.
claimThe corpus luteum produces estrogen and high amounts of progesterone to prepare the uterine lining for embryo implantation.
claimIf no embryo implants, the corpus luteum degenerates, causing circulating hormone levels to decline and the endometrium to shed, resulting in menstrual bleeding.
measurementIf pregnancy occurs, the corpus luteum produces progesterone until approximately 10 weeks of gestation.
claimProgesterone, manufactured by the corpus luteum, is the hormone responsible for changes in the uterus that support a fertilized egg during the luteal phase.
Reproductive Hormones endocrine.org Jan 24, 2022 4 facts
claimThe placenta secretes progesterone after it develops, which supports the corpus luteum and maintains elevated progesterone levels throughout pregnancy to prevent the production of additional eggs.
claimThe corpus luteum breaks down if a woman does not become pregnant, which lowers progesterone levels and triggers menstruation.
claimThe corpus luteum, a temporary endocrine gland produced by the female body after ovulation during the second half of the menstrual cycle, secretes progesterone.
claimRelaxin is a hormone secreted in the ovary by the corpus luteum, and during pregnancy, it is also released by the placenta and the uterine lining.
Understanding the Menstrual Cycle: A Breakdown of Its Four Phases raleighob.com Jan 15, 2025 4 facts
claimAfter ovulation, the ruptured follicle transforms into the corpus luteum, which secretes progesterone.
claimFollowing ovulation, luteinizing hormone levels decrease but remain essential to support the activity of the corpus luteum.
claimIf an egg is fertilized and implants, the body produces human chorionic gonadotropin (hCG), which signals the corpus luteum to continue secreting progesterone to maintain the uterine lining and support early pregnancy.
claimIf an egg is not fertilized, the corpus luteum breaks down, causing a drop in progesterone levels that triggers the shedding of the uterine lining and the start of the next menstrual cycle.
Understanding the Phases of the Menstrual Cycle - Clue helloclue.com 3 facts
measurementIf pregnancy does not occur, the corpus luteum breaks down after about 9-11 days.
claimDuring the luteal phase of the ovarian cycle (which corresponds to the secretory phase of the uterine cycle), the corpus luteum forms and releases hormones to prepare for a possible pregnancy.
claimAfter ovulation, the empty follicle transforms into the corpus luteum, which produces progesterone and some estrogen to support a potential pregnancy.
Follicular Phase Of Menstrual Cycle - Cleveland Clinic my.clevelandclinic.org Aug 8, 2022 2 facts
claimThe corpus luteum produces pregnancy hormones; if pregnancy does not occur, the corpus luteum disappears and the uterus lining is shed during menstruation.
claimThe luteal phase begins after ovulation, when the dominant follicle that released the mature egg changes into a structure called the corpus luteum.
Menstrual Cycle Phases: Decoding the Stages - Perelel perelelhealth.com Oct 22, 2024 2 facts
claimThe corpus luteum produces progesterone, which facilitates blood flow and nourishment to the uterine lining to support a potential fertilized egg.
quote“The luteal phase gets its name because once the follicle releases the egg, there’s a leftover structure that is called the corpus luteum,” explains Dr. O’Connor.
Female reproductive organs: Anatomy and functions kenhub.com 2 facts
claimThe corpus luteum degenerates into a fibrous scar tissue called the corpus albicans.
claimDuring the luteal phase (days 14-28) of the ovarian cycle, the ovarian follicle transforms into a hormone-secreting corpus luteum, which corresponds to the secretory phase of the uterine cycle where the endometrium becomes a nutritionally rich environment for implantation.
Female Reproductive System: Structure & Function my.clevelandclinic.org Nov 28, 2022 2 facts
procedureThe luteal phase begins immediately after ovulation, during which the empty ovarian follicle develops into the corpus luteum, which secretes estrogen and progesterone to prepare the uterus for a fertilized egg.
claimFollowing ovulation, the empty ovarian follicle develops into the corpus luteum, which secretes estrogen and progesterone.
4 Phases of Menstrual Cycle: Hormone Changes Chart - Liv Hospital int.livhospital.com Mar 19, 2026 1 fact
claimIf pregnancy does not occur, the corpus luteum breaks down, leading to a decrease in estrogen and progesterone levels, which initiates the start of a new menstrual cycle.
The Reproductive System | Loma Linda University Fertility lomalindafertility.com 1 fact
claimAfter ovulation, the ovarian follicle transforms into the corpus luteum, which produces progesterone.