concept

classical serotonergic psychedelics

Also known as: classic psychedelics, classical psychedelics, classical serotonergic psychedelics

Facts (12)

Sources

Published Studies — Johns Hopkins Center for Psychedelic and ... hopkinspsychedelic.org Johns Hopkins Center for Psychedelic and Consciousness Research 9 facts

referenceYaden, Y. B., Berghella, A. P., Regier, P. S., Garcia-Romeu, A., Johnson, M. W., and Hendricks, P. S. published 'Classic psychedelics in the treatment of substance use disorder: Potential synergies with twelve-step programs' in the International Journal of Drug Policy in 2021.

referenceGukasyan, N. and Narayan, S. K. published 'Menstrual Changes and Reversal of Amenorrhea Induced by Classic Psychedelics: A Case Series' in the Journal of Psychoactive Drugs in 2023.

referenceA 2018 review by Johnson, Hendricks, Barrett, and Griffiths provided an integrative analysis of classic psychedelics covering epidemiology, therapeutics, mystical experience, and brain network function.

referenceThe position statement 'Challenges with clinical trial participants in studies with classical psychedelics' was published in the Journal of Psychopharmacology in 2026 by the National Network of Depression Centers’ task group on psychedelics and related compounds, including authors Lewis, B. R., Reid, M. J., Novick, A. M., Byrne, K., Niciu, M. J., Fonzo, G. A., Meyer, T. D., Feifel, D., El-Mallakh, R. S., Soares, J., Suppes, T., and Barrett, F. S.

referenceE. Ehrenkranz, M. Agrawal, and D. B. Yaden authored a paper titled 'Adverse events in studies of classic psychedelics: A systematic review and meta-analysis' published in JAMA Psych in 2024.

referenceA 2024 review published in Pharmacological Research (IUPHAR-review) examined the integration of classic psychedelics into current treatment models for substance use disorders.

referenceEhrenkranz et al. published a study in JAMA Psychiatry in 2024 regarding adverse events in studies of classic psychedelics.

referenceThe article 'Trends in the Top-Cited Articles on Classic Psychedelics' by D. W. Lawrence, B. Sharma, R. R. Griffiths, and R. Carhart-Harris was published in the Journal of Psychoactive Drugs in 2021.

referenceThe study 'Association between lifetime co-use of classic psychedelics and cannabis and prostate cancer diagnosis among US adults 50 years and older' was published in Scientific Reports in 2025 by Baral, A., Pan, Y., Hlaing, W. M., Garcia-Romeu, A., Pinheiro, P. S., and Vidot, D. C.

Ancient Roots of Today's Emerging Renaissance in ... link.springer.com Springer 2 facts

claimClassic psychedelics initiate a cascade of altered neural connectivity and blood-flow across brain regions including the default-mode network (medial prefrontal cortex, posterior cingulate cortex, inferior parietal lobule, lateral temporal cortex, hippocampus, and precuneus), the amygdala, the thalamus, and the claustrum.

claimClassic psychedelics, including psilocybin, LSD, and ayahuasca, exert their primary effects through the serotonin 2A (5-HT2A) receptor, which is heavily expressed throughout the cortex.

Psychedelics, Sociality, and Human Evolution frontiersin.org Frontiers 1 fact

referenceGoldberg et al. (2020b) performed a systematic review and meta-analysis on the post-acute psychological effects of classical serotonergic psychedelics.