concept

cisplatin

Also known as: cisplatin chemotherapy

Facts (7)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 4 facts

claimCisplatin-based chemotherapy in non-small cell lung cancer inactivates p53 and induces Tribbles Pseudokinase 1 expression, leading to stemness activation in cancer cells.

claimThe combination of cisplatin and a histone deacetylase inhibitor may synergistically suppress the progression of non-small cell lung cancer.

claimCisplatin-enriching cancer stem cells confer multidrug resistance in non-small cell lung cancer by enhancing TRIB1 and HDAC activity, as reported by et al. in Cell Death & Disease (2017).

claimChemotherapeutic agents including etoposide (NCT00878449), irinotecan (NCT01009073), cisplatin (NCT00878449), paclitaxel (NCT00891605), docetaxel (NCT00888108), and gemcitabine (NCT00887757) have been tested in combination with navitoclax to treat various cancers.

Perspectives on cancer therapy—synthetic lethal precision medicine ... nature.com Nature Apr 16, 2025 2 facts

referenceA phase I study by Leijen et al. (2016) evaluated the WEE1 inhibitor AZD1775 as monotherapy and in combination with gemcitabine, cisplatin, or carboplatin in patients with advanced solid tumors.

referenceA 2016 phase I study published in the Journal of Clinical Oncology by Leijen et al. evaluated the Wee1 inhibitor AZD1775 as monotherapy and in combination with gemcitabine, cisplatin, or carboplatin in patients with advanced solid tumors.

Homeostatic medicine: a strategy for exploring health and disease link.springer.com Springer Sep 26, 2022 1 fact

claimThrough the nitrate-nitrite-NO pathway, nitrate performs NO-like physiological functions including protecting the digestive system by increasing blood flow and regulating intestinal flora, alleviating obesity by adjusting fat metabolism, and assisting tumor therapy by increasing sensitivity to cisplatin chemotherapy.