concept

chronic lymphocytic leukemia

Also known as: B-cell chronic lymphocytic leukemia, CLL, chronic lymphoblastic leukemia

Facts (2)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 2 facts

measurementA phase II study (NCT01087151) demonstrated that in patients with chronic lymphocytic leukemia, the combination of rituximab and navitoclax exhibits higher effectiveness, prolonged progression-free survival, and better tolerance compared to rituximab monotherapy.

claimA phase 2 study evaluated the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263), with or without rituximab, in previously untreated B-cell chronic lymphocytic leukemia.