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cell-mediated immunity
Also known as: cell-mediated immune system
Facts (13)
Sources
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 13 facts
claimClinical folate deficiency, known as megaloblastic anemia, results in impaired cell-mediated immune responses, which can be restored by folic acid supplementation.
claimNutrient deficiencies can impair phagocytic function in innate immunity and adversely affect adaptive immunity, including cytokine production, antibody-mediated immunity, and cell-mediated immunity.
claimSelenium deficiency impairs aspects of innate and adaptive immunity, adversely affecting both humoral immunity (antibody production) and cell-mediated immunity.
claimSelenium supplementation improves cell-mediated immunity in deficient individuals and enhances the immune response to viruses, but may worsen allergic asthma and impair the immune response to parasites.
referenceKennes B, Dumont I, Brohee D, Hubert C, and Neve P published a study in the journal Gerontology in 1983 regarding the effect of vitamin C supplements on cell-mediated immunity in elderly individuals.
claimFolic acid deficiency causes megaloblastic anemia, which is associated with depressed cell-mediated immunity, according to a 1975 study by Gross et al. published in the American Journal of Clinical Nutrition.
claimCell-mediated immunity is carried out by T cells, which are lymphocytes that develop in the thymus.
claimVitamin A deficiency may affect cell-mediated immunity by decreasing the number or distribution of T cells, altering cytokine production, or decreasing the expression of cell-surface receptors that mediate T-cell signaling.
claimIn obese children and adolescents, impairments in cell-mediated immunity have been associated with deficiencies in zinc and iron.
claimVitamin E deficiency impairs both humoral and cell-mediated aspects of adaptive immunity, including B and T cell function, according to studies in animal models and humans.
claimLeptin functions include the modulation of inflammatory responses and aspects of humoral and cell-mediated responses of the adaptive immune system.
claimProtein-energy malnutrition (PEM) primarily affects cell-mediated aspects of adaptive immunity rather than humoral immunity components.
claimVitamin B6 deficiency impairs aspects of adaptive immunity, including both humoral and cell-mediated immunity, specifically affecting lymphocyte proliferation, differentiation, and maturation, as well as cytokine and antibody production.