Knowledge Tree
cell death
Facts (12)
Sources
Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Apr 16, 2018 6 facts
claimStem cells regulate their transcriptional machinery in response to environmental stimuli to choose between maintaining stemness or exiting stemness, which leads to either differentiation or cell death.
claimMitochondrial priming allows pluripotent stem cells to rapidly undergo cell death following DNA damage.
claimMitochondria regulate cellular homeostasis and cell survival versus death outcomes by modulating redox and calcium balance.
referenceTait and Green (2010) reviewed the role of mitochondria in cell death, specifically focusing on outer membrane permeabilization.
claimStem cells require constant and tight regulation of cell death to preserve genome integrity and ensure the faithful derivation of functional progeny.
claimAdult stem cells are generally considered more resistant to cell death than pluripotent stem cells, though they may still undergo cell death in response to DNA damage.
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 2 facts
referenceLiu S, Yao S, Yang H, Liu S, and Wang Y authored 'Autophagy: Regulator of cell death', published in Cell Death & Disease in 2023 (14:648, doi: 10.1038/s41419-023-06154-8).
referenceSpermidine attenuates bleomycin-induced lung fibrosis in mice by inducing autophagy and inhibiting endoplasmic reticulum stress (ERS)-induced cell death, as found by Baek et al. in Experimental & Molecular Medicine (2020).
Chronic inflammation in the etiology of disease across the life span nature.com Dec 5, 2019 1 fact
referencePyroptosis and necroptosis are distinct forms of cell death with specific similarities, differences, and crosstalk.
Rusty Gage, PhD - Salk Institute salk.edu 1 fact
referenceB.H. Spain, C.J. Larson, L.S. Shihabuddin, F.H. Gage, and I.M. Verma reported in the Journal of Neuroscience (2000) that viral expression of expanded polyglutamine tracts in the adult rat brain leads to intraneuronal aggregate formation and cell death.
Medicinal plants: bioactive compounds, biological activities ... frontiersin.org 1 fact
claimBioactive chemicals in medicinal plants enhance microbial membrane permeability, leading to the efflux of cellular constituents and cell death.
The Energy Homeostasis Principle: A Naturalistic Approach to ... frontiersin.org 1 fact
claimNeural activity can be interpreted as energy expenditure, which acts as an environmental pressure forcing neurons to balance their energy budget to prevent cell death.