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CAR T-cell therapy
Also known as: CAR-T, chimeric antigen receptor T-cell therapy, CAR T-cell therapies
Facts (6)
Sources
Top Oncology Innovations That Shaped the First Half of 2025 binaytara.org Jul 21, 2025 3 facts
claimImmune checkpoint inhibitors and CAR T-cell treatments can trigger immune responses affecting virtually any organ, sometimes necessitating prolonged immunosuppression or resulting in chronic health problems.
claimSolid tumors, including gastrointestinal, lung, and skin cancers, are more commonly targeted by tumor-infiltrating lymphocyte (TIL) therapies and T-cell receptor (TCR) therapies rather than CAR T-cell therapies.
claimImmunotherapy treatments, including immune checkpoint inhibitors and CAR T-cell therapies, are associated with adverse events ranging from mild skin reactions and gastrointestinal symptoms to severe immune-related toxicities such as colitis, hepatitis, pneumonitis, and endocrinopathies.
The breakthroughs behind UT MD Anderson's quest to end cancer nature.com 2 facts
claimExperimental CAR-NK cell treatments could potentially be used off-the-shelf against many cancers, unlike CAR-T-cell therapy, provided that the correct source of NK cells is identified.
claimModifying the microenvironment, described as 'warming up' or 'cooling down', may help improve outcomes for patients with large B cell lymphomas who do not respond to CAR-T-cell therapy.
10 Breakthrough Research and Clinical Trials Shaping the ... honcology.com Dec 29, 2025 1 fact
claimRecent cancer research and clinical trials have produced advanced immunotherapies such as CAR-T cell therapy.