concept

cancer progression

Also known as: cancer progression, tumor progression

Facts (7)

Sources

Integrating allostasis and emerging technologies to study complex ... nature.com Nature Nov 5, 2025 3 facts

claimDysregulation from allostatic load contributes to DNA damage, immune suppression, and chronic inflammation, which are hallmarks of tumor initiation, progression, and metastasis.

perspectiveMolecular experiments using cell- and animal-based models are necessary to investigate how chronic stress-induced allostatic state changes mechanistically contribute to tumor initiation and progression, bridging the gap between observational findings and causative biological pathways.

claimMetabolic and inflammatory dysregulation contributes to DNA damage, immune suppression, and chronic inflammation, which are hallmarks of tumor initiation, progression, and metastasis.

Dietary interventions as regulators of stem cell behavior in ... genesdev.cshlp.org Genes & Development 1 fact

referenceGeneral dysbiosis caused by a high-fat diet is associated with tumor progression due to a lack of secreted butyrate as a waste product by the microbiota.

Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Springer Apr 16, 2018 1 fact

claimContrary to the initial postulate by Warburg that mitochondria in cancer cells are defective, current evidence indicates that mitochondria are essential for tumor growth and progression and may serve as a therapeutic target.

Editorial: Inflammation and chronic disease - Frontiers frontiersin.org Frontiers Jul 1, 2024 1 fact

claimElevated levels of vascular adhesion protein-1 (VAP-1), a dual-function glycoprotein involved in inflammation and tumor progression, are associated with an increased 12-year risk of cancer incidence, cancer mortality, and all-cause mortality in a Taiwanese population, with predictive performance exceeding that of smoking, according to Chen et al.

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 1 fact

referenceC.C. Hsu, D. Peng, Z. Cai, and H.K. Lin published 'AMPK signaling and its targeting in cancer progression and treatment' in Seminars in Cancer Biology in 2022, discussing the role of AMPK signaling in cancer progression and its potential as a therapeutic target.