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caloric restriction
Also known as: CR, calorie restriction
Facts (25)
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Dietary interventions as regulators of stem cell behavior in ... genesdev.cshlp.org 15 facts
claimCaloric restriction, a high-fat diet, and fasting all converge on enhanced crypt proliferation and survival in both homeostasis and injury-based regenerative programs, though they may utilize different underlying mechanisms.
claimComparisons between caloric restriction/prolonged fasting, the ketogenic diet, and high-fat diets suggest the importance of the balance between glucose and fatty acid utilization as oxidative substrates in stem cells.
claimCaloric restriction is defined as either reducing calorie intake by >20% over ad libitum feeding or lengthening the time between meals, according to Pugh et al. (1999).
claimCaloric restriction promotes mTORC1-dependent enhanced self-renewal in intestinal stem cells, primarily through changes induced by the Paneth cell niche.
claimCaloric restriction favors the preservation and function of muscle satellite cells, hematopoietic stem cells, and hair follicle stem cells in both young and old animals, according to studies by Cerletti et al. (2012), Tang et al. (2016), and Forni et al. (2017).
measurementSystemic levels of β-hydroxybutyrate (β-OHB) increase to millimolar concentrations during fasting, caloric restriction, and ketogenic diets, largely due to hepatic production, as reported by Cahill et al. in 1966 and Shimazu et al. in 2013.
claimCaloric restriction, prolonged fasting, ketogenesis, and high-fat diets all diminish the levels of circulating glucose.
claimThe most thoroughly studied dietary interventions for altering organismal metabolism include caloric restriction, prolonged fasting, the ketogenic diet, and the high-fat “Western” diet.
claimCaloric restriction enhanced the repair ability of muscle satellite cells in studies by Cerletti et al. (2012).
claimCalorie restriction increases the fitness of circulating memory T lymphocytes, which then home to the bone marrow and promote the survival of hematopoietic stem cells (HSCs), according to Collins et al. (2019).
claimCaloric restriction can reshape the local hair follicle stem cell (HFSC) niche by decreasing white adipose depots in the dermis.
claimCaloric restriction, prolonged fasting, and the ketogenic diet elicit similar systemic changes to metabolic homeostasis, though they operate through slightly different mechanisms.
claimCirculating lipid availability increases under conditions of caloric restriction, the ketogenic diet, and Western diets, and the accompanying increased fatty acid oxidation provides insights into the convergence of phenotypes observed with these diets, as noted by Corton et al. (2004), Sikder et al. (2018), Steinhauser et al. (2018), and Rosenbaum et al. (2019).
claimCaloric restriction improved the repopulation capacity but impaired the lymphoid differentiation capacity of hematopoietic stem cells (HSCs) in the bone marrow, as reported by Tang et al. (2016).
referenceCaloric restriction increases both intestinal stem cell (ISC) and Paneth cell numbers, as reported by Yilmaz et al. in 2012.
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 8 facts
claimA two-month intervention of calorie restriction (CR) in early life can enhance the amplitude of core clocks in the liver.
claimA functional circadian clock system is necessary for calorie restriction (CR)-mediated lifespan extension, as calorie restriction fails to extend the lifespan of BMAL1 knockout mice.
claimMendoza J., Drevet K., Pevet P., and Challet E. concluded that daily meal timing is not necessary for resetting the main circadian clock by calorie restriction in a 2008 study published in the Journal of Neuroendocrinology.
referenceKim, D. H. et al. published a study in 2020 titled 'Anti-aging effects of calorie restriction (CR) and CR mimetics based on the senoinflammation concept' in Nutrients, which discusses the anti-aging effects of calorie restriction and calorie restriction mimetics in the context of senoinflammation.
claimCalorie restriction (CR) modifies circadian clocks through BMAL1-dependent and BMAL1-independent transcriptional and post-transcriptional mechanisms.
claimCalorie restriction (CR), a dietary regimen low in energy without malnutrition, decreases the occurrence of age-related diseases and extends lifespan by controlling the circadian clock.
claimCalorie restriction (CR) impacts the central oscillator and entrains the suprachiasmatic nucleus (SCN) clock, influencing the SCN clockwork’s temporal organization, circadian outputs under the light-dark cycle, and circadian system photic responses during the daytime.
claimPatel S. A., Chaudhari A., Gupta R., Velingkaar N., and Kondratov R. V. found that circadian clocks govern calorie restriction-mediated life span extension through BMAL1- and IGF-1-dependent mechanisms in a 2016 study published in The FASEB Journal.
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 1 fact
referenceHam, D.J., Börsch, A., Chojnowska, K., Lin, S., Leuchtmann, A.B., Ham, A.S., et al. (2022) investigated the distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle, published in Nature Communications.
Western pattern diet - Wikipedia en.wikipedia.org 1 fact
referenceThe study 'Source of Dietary Carbohydrate Affects Life Span of Fischer 344 Rats Independent of Caloric Restriction' by Murtagh-Mark et al. (1995) found that the source of dietary carbohydrates affects the lifespan of Fischer 344 rats independently of caloric restriction.