Also known as: BRCA2, BRCA1/2, BRCA
BRCA1 is a genetic mutation directly linked to the development of breast cancer as noted in [1], and clinical trials for targeted therapies like olaparib specifically target patients with BRCA1-mutated breast cancer as described in [2] and [3].
The concept of synthetic lethality is directly linked to BRCA1 through genome-scale CRISPR-Cas9 screens that identify specific genes essential for the survival of BRCA1-deficient cells, as described in [1].
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