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brain-derived neurotrophic factor
Also known as: BDNF
Facts (12)
Sources
Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Dec 19, 2024 6 facts
claimPsychedelics produce electrophysiological changes that stimulate neurotrophic signaling, including the signaling of Brain-Derived Neurotrophic Factor (BDNF), which is a key promoter of synaptic plasticity and neuronal survival.
measurementIn treatment-resistant depression (TRD) patients, non-responsiveness to ketamine treatment is correlated with decreased brain-derived neurotrophic factor (BDNF) levels 7 and 14 days after a single 0.5 mg/kg ketamine infusion.
claimThe metabolite 2R,6R-HNK may contribute to the positive effects of ketamine on neurogenesis through the upregulation of brain-derived neurotrophic factor (BDNF).
claimKetamine treatment in patients with major depressive disorder induces plasticity, as indicated by concomitant changes in Brain-Derived Neurotrophic Factor (BDNF) levels and sleep slow waves.
claimHarmala alkaloids increase levels of brain-derived neurotrophic factor (BDNF) and promote the survival of newborn neurons in the hippocampus.
claimFukumoto et al. (2019) demonstrated that activity-dependent brain-derived neurotrophic factor (BDNF) signaling is required for the antidepressant effects of (2R,6R)-hydroxynorketamine.
Rusty Gage, PhD - Salk Institute salk.edu 4 facts
referenceGrafts of fibroblasts genetically modified to secrete NGF, BDNF, NT-3, or basic FGF elicit differential responses in the adult spinal cord, according to a 1996 study published in Cell Transplantation.
referenceBrain-derived neurotrophic factor-transduced fibroblasts produce BDNF and affect the adult rat brain when grafted, as described by Lucidi-Phillipi et al. in a 1995 Journal of Comparative Neurology study.
referenceBrain-derived neurotrophic factor and nerve growth factor affect remaining neurons in the lesioned nucleus basalis magnocellularis, as reported by Tuszynski, M.H., Peterson, D.A., Ray, J., Baird, A., Nakahara, Y., and Gage, F.H. in 1994.
referenceD.M. McTigue, P.J. Horner, B.T. Stokes, and F.H. Gage authored the paper 'Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord' published in the Journal of Neuroscience in 1998 (Volume 18, Issue 14, pages 5354-65).
Neuroimaging in psychedelic drug development: past, present, and ... nature.com Sep 27, 2023 1 fact
claimEvidence of potential neuroplastic effects of psychedelics in humans has been observed in studies involving low-dose LSD and ayahuasca, both of which showed increased serum levels of brain-derived neurotrophic factor (BDNF) in active treatment groups.
The Importance of Play for Children - National Institute for Play nifplay.org 1 fact
referencePlay enhances adaptive and prosocial behaviors by increasing the production of brain-derived neurotrophic factor (BDNF), which is crucial for brain development (Panksepp, 1998; Burghardt, 2005).