Knowledge Tree
blood-brain barrier
Facts (12)
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Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 6 facts
claimNanocarriers, including liposomes, polymeric micelles, nanogels, and vesicles derived from herbal medicines, improve the transport and effectiveness of medicinal plant-based chemicals by enhancing solubility, extending residence time in the body, and facilitating passage through biological barriers like the blood–brain barrier.
referenceSun et al. (2024) demonstrated that quercetin protects blood–brain barrier integrity via the PI3K/Akt/Erk signaling pathway in a mouse model of meningitis induced by Glaesserella parasuis.
claimGinkgolides from Ginkgo biloba and baicalin from Scutellaria baicalensis protect the blood–brain barrier by stabilizing tight junction complexes and decreasing oxidative stress and inflammation.
claimFlavonoids, including quercetin from onions and apples, rutin from buckwheat, and anthocyanins from blueberries and blackberries, bolster blood–brain barrier integrity by fortifying tight junction proteins and diminishing oxidative stress-induced permeability.
claimHesperidin from citrus fruits and catechins from green tea enhance the expression of claudin-5, occludin, and zonula occludens-1 proteins, which are critical for preserving blood–brain barrier function.
claimResearch is ongoing to determine appropriate dose regimes and delivery techniques for blood–brain barrier protection that ensure sufficient brain penetration for neuroprotective efficacy.
“Plants of the Gods” and their hallucinogenic powers in ... surgicalneurologyint.com Jul 19, 2021 2 facts
claimCocaine acts as an indirect sympathomimetic drug that crosses the blood–brain barrier and blocks the transport of dopamine, serotonin, and norepinephrine, which inhibits the re-uptake of these neurotransmitters at presynaptic terminals and increases their quantity and receptor activation in postsynaptic neurons.
claimPsilocybin and psilocin are lipophilic compounds, which allows them to cross the blood-brain barrier and act as potent hallucinogens.
From Homeostasis to Allodynamic Regulation (Chapter 18) cambridge.org 1 fact
referenceBanks, W. A. & Farrell, C. L. published 'Impaired transport of leptin across the blood–brain barrier in obesity is acquired and reversible' in 2003.
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 1 fact
referenceCostea et al. (2019) examined the blood-brain barrier and its intercellular junctions in the context of age-related brain disorders.
A Double-Edged Sword: Inflammation and Your Health - Cedars-Sinai cedars-sinai.org Feb 12, 2021 1 fact
claimThe blood-brain barrier acts as a physical barricade to prevent toxins from accessing healthy brain tissue, while microglia cells travel through the brain to monitor for danger.
Neuroimaging in psychedelic drug development: past, present, and ... nature.com Sep 27, 2023 1 fact
referenceDeo AK, Theil FP, and Nicolas JM published 'Confounding parameters in preclinical assessment of blood-brain barrier permeation: An overview with emphasis on species differences and effect of disease states' in Molecular Pharmaceutics in 2013.