Knowledge Tree
biofilm
Also known as: biofilm, biofilms
Facts (32)
Sources
Medicinal plants: bioactive compounds, biological activities ... frontiersin.org 28 facts
measurementAt a concentration of 200 grams/ml, (+)-nootkatone decreased biofilm by 50% and eradicated 80% of bacterial cells.
claimThe intrinsic antibiotic resistance of Pseudomonas aeruginosa enables its survival under extreme environmental conditions, including biofilms in healthcare settings.
claimBiofilms are protective matrices created by multidrug-resistant (MDR) microorganisms that render them resistant to antibiotics.
measurementC. quadrangular extracts at doses of 0.625, 0.313, and 0.156 mg/ml eliminated pre-existing MRSA and MDRAB biofilms.
claimEnterococci rely on biofilm formation to facilitate the development of endodontic infections, urinary system infections, and endocarditis.
claimThe alkaloid berberine derived from apple inhibits biofilm formation in multidrug-resistant Escherichia coli by disrupting the synthesis of biofilm-related compounds.
claimFarha et al. investigated the efficacy of (+)-nootkatone against biofilms of multidrug-resistant Staphylococcus aureus and analyzed its hypothesized molecular mechanism.
claimModgil et al. (2024) investigated the association of putative virulence genes with HEp-2 cell adherence and biofilm production in enteroaggregative E. coli strains isolated from acute diarrheal and healthy children in India.
claimEugenol is a phyto-compound effective against methicillin-resistant and methicillin-sensitive Staphylococcus aureus clinical strain biofilms.
claimThe prenyflavanone 8PP inhibits Candida albicans biofilms by enhancing the generation of reactive oxygen and nitrogen species.
referenceMichaelis and Grohmann (2023) reviewed the horizontal gene transfer of antibiotic resistance genes in biofilms.
claimPolyphenols and tannins disrupt quorum sensing, which is a critical communication mechanism for biofilm development.
claimThe virulence factors of Staphylococcus aureus are defined by mechanisms of invasion and proliferation, production of extracellular substances, toxin production, and the capacity to form biofilms.
referenceFarha AK, Yang QQ, Kim G, Zhang D, Mavumengwana V, Habimana O, et al. authored 'Inhibition of multidrug-resistant foodborne Staphylococcus aureus biofilms by a natural terpenoid (+)-nootkatone and related molecular mechanism' published in Food Control in 2020.
claimCurcumin derived from Curcuma longa suppresses biofilm formation in Pseudomonas aeruginosa by downregulating quorum sensing-related genes.
claimEugenol efficiently eradicates Staphylococcus aureus biofilms in vivo, diminishes the expression of genes linked to biofilms and enterotoxins, disrupts the cell membrane, and results in the release of cellular contents.
claimCandida strains can form biofilms on medical equipment, which contributes to their resistance to antifungal agents.
claimLight microscopy and confocal laser scanning microscopy demonstrated that (+)-nootkatone significantly diminishes biofilm thickness in Staphylococcus aureus.
claimPseudomonas aeruginosa biofilms are resistant to aminoglycosides because the organisms secrete alginate, which binds to the positively charged aminoglycoside antibiotics.
claimInfections caused by coagulase-negative Staphylococcus epidermidis are prevalent in patients with implanted medical devices, potentially due to the bacterium's ability to build biofilms.
claimFlavonoids can elicit aberrant multicellular aggregation in Staphylococcus aureus, which inhibits the formation of structured biofilm formations.
referenceKhaleghian et al. (2023) published a study in Frontiers in Microbiology on the in silico design and mechanistic study of niosome-encapsulated curcumin against multidrug-resistant Staphylococcus aureus biofilms.
claimThe alkaloid sanguinarine derived from apple inhibits biofilm formation in Proteus rettgeri by disrupting the synthesis of biofilm-related compounds.
claimBiofilms resist antimicrobials because the extracellular polymeric substances (EPS) layer impedes the penetration of antibiotics.
referenceBhattacharya et al. (2015) evaluated multidrug-resistant Staphylococcus aureus and its association with biofilm production in a tertiary care hospital in Tripura, Northeast India.
referencePanda et al. studied the use of Indian medicinal plant extracts to control multidrug-resistant Staphylococcus aureus, including strains in biofilms.
claimPlumbago zeylanica extract interferes with quorum sensing-regulated bacterial virulence factors and biofilms, according to a 2021 study by Qais et al.
claimCompounds derived from medicinal plants can impede biofilm growth or dismantle pre-existing biofilms.
Pharmacological Uses of New Bioactive Compounds from Medicinal ... ouci.dntb.gov.ua 1 fact
claimThymus vulgaris extracts exhibit an inhibitory effect on the planktonic form and biofilm structures of six human pathogenic bacteria.
Pharmacological Uses of New Bioactive Compounds from Medicinal ... academia.edu 1 fact
claimMohsenipour and Hassanshahian (2015) demonstrated that Thymus vulgaris extracts have an inhibitory effect on the planktonic form and biofilm structures of six human pathogenic bacteria.
Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us 1 fact
claimSilymarin destabilizes mature biofilms, inhibits the secretion of hydrolases, and mediates the destruction of the membrane in Candida albicans, according to Yun et al. (reference 88).
A shift from synthetic to bio-based polymer for functionalization of ... ouci.dntb.gov.ua 1 fact
referenceBrethauer et al. published 'Impacts of biofilms on the conversion of cellulose' in Applied Microbiology and Biotechnology (Volume 104, page 5201), discussing how biofilms affect the conversion processes of cellulose.