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ATR inhibitors
Also known as: ataxia telangiectasia and Rad3-related inhibitors, ATR inhibitor, ATR inhibition
Facts (2)
Sources
Perspectives on cancer therapy—synthetic lethal precision medicine ... nature.com Apr 16, 2025 2 facts
claimThe ATR inhibitor M4344 is capable of killing cancer cells with replication stress and enhances the chemotherapeutic activity of widely used DNA damaging agents.
referenceA 2018 phase I study published in the Journal of Clinical Oncology by Thomas et al. evaluated the ATR inhibitor M6620 in combination with topotecan in patients with advanced solid tumors.