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antigen-presenting cells
Also known as: APCs
Facts (11)
Sources
Parts of the Immune System | Children's Hospital of Philadelphia chop.edu 6 facts
claimMacrophages primarily destroy pathogens, signal the innate immune response, and cause inflammation, though they are also capable of serving as antigen-presenting cells.
procedureDendritic cells, macrophages, and B cells must travel to the draining lymph node to activate the adaptive immune response when acting as antigen-presenting cells.
claimWhen macrophages function as antigen-presenting cells, they typically present antigens from pathogens that have evolved to evade typical innate immune responses.
claimThe adaptive immune response is driven by the activities of antigen-presenting cells (APCs).
claimDendritic cells, macrophages, and B cells are the three cell types that can serve as antigen-presenting cells (APCs).
claimB cells are an essential part of the adaptive immune response and can serve as antigen-presenting cells (APCs) to activate responses against toxins or smaller antigens like proteins.
3. The Innate Immune System - Immunopaedia immunopaedia.org.za 3 facts
claimMacrophages function in adaptive immune responses as antigen-presenting cells and as targets for cellular and humoral adaptive responses, where they are activated by T cell-derived cytokines and antibodies.
claimDendritic cells function as elements of the innate immune system and as antigen-presenting cells for T cell activation, effectively linking innate and adaptive immune responses.
claimMarginal zone B (MZ B) cells are easily activated by low levels of antigen, act as potent antigen-presenting cells for naive T cells, and produce short-lived IgM antibody-forming cells involved in early defense against blood-borne pathogens and autoreactive B cell responses.
The components of the immune system - Immunobiology - NCBI - NIH ncbi.nlm.nih.gov 1 fact
claimDendritic cells enter tissues as immature phagocytes to ingest antigens and subsequently migrate into lymphoid tissue as antigen-presenting cells.
Chronic Inflammation - StatPearls - NCBI Bookshelf ncbi.nlm.nih.gov 1 fact
claimTissue macrophages and dendritic cells contribute to antigen clearance through phagocytosis, the release of cytokines, and by serving as antigen-presenting cells to lymphocytes.