Knowledge Tree
antibiotic resistance
Also known as: antibacterial resistance
Facts (26)
Sources
Medicinal plants: bioactive compounds, biological activities ... frontiersin.org 20 facts
claimThe rise of superbugs like MRSA, difficulties in treating device-related infections, and the adverse effects of high-dose antibiotic therapy create a detrimental loop that increases the demand for higher antibiotic dosages and worsens antibiotic resistance.
referenceVale de Macedo GH, Costa GD, Oliveira ER, Damasceno GV, Mendonça JS, Silva LD, et al. published 'Interplay between ESKAPE pathogens and immunity in skin infections: An overview of the major determinants of virulence and antibiotic resistance' in the journal Pathogens in 2021 (Volume 10, Issue 148).
referenceAlgammal AM, Hetta HF, Elkelish A, Alkhalifah DH, Hozzein WN, Batiha GE, et al. published 'Methicillin-resistant Staphylococcus aureus (MRSA): One health perspective approach to the bacterium epidemiology, virulence factors, antibiotic-resistance, and zoonotic impact' in Infection and Drug Resistance in 2020.
claimNatural products derived from medicinal plants exhibit significant potential for addressing antibiotic resistance in bacterial pathogens.
claimThe intrinsic antibiotic resistance of Pseudomonas aeruginosa enables its survival under extreme environmental conditions, including biofilms in healthcare settings.
referenceUrban-Chmiel et al. (2022) published a review on the state of antibiotic resistance in bacteria.
claimMethanol extract from cardamom fruit is used as a replacement drug and in scientific research to address antibiotic resistance, acting against Staphylococcus aureus through ionic and electrostatic interactions that cause cellular membrane instability and disintegration.
referenceHammer et al. (2012) studied the effects of Melaleuca alternifolia (tea tree) essential oil and its major monoterpene component, terpinen-4-ol, on the development of antibiotic resistance and antimicrobial susceptibility.
claimGenetic alterations, including point mutations, deletions, insertions, or the horizontal transfer of resistant genes, can result in the development of antibiotic resistance in bacteria.
claimPlant extracts present viable alternatives to traditional antibiotics, which are progressively losing efficacy due to the escalating issue of antibiotic resistance.
claimPseudomonas aeruginosa exhibits antibiotic resistance through innate, acquired, and adaptive mechanisms, including modifications in chromosomal genes located at efflux and target sites.
claimAntibiotic resistance is defined as the state where a bacterium becomes unresponsive to previously effective medications.
referenceIskandar et al. published a review titled 'Drivers of antibiotic resistance transmission in low-and middle-income countries from a “one health” perspective' in the journal Antibiotics in 2020.
claimBioactive compounds in medicinal plant extracts can improve the effectiveness of current antibiotics and help prevent the development of antibiotic resistance.
referenceCoastal plants and marine organisms possess antibacterial potential that can be utilized to combat antibacterial resistance, as reviewed in the Malaysian Journal of Microbiology in 2024.
claimPlant-derived chemicals can address microbial resistance by inhibiting efflux pumps, which are a primary mechanism of antibiotic resistance in multidrug-resistant (MDR) bacteria.
referenceAl-Mebairik NF, El-Kersh TA, Al-Sheikh YA, and Marie MAM published 'A review of virulence factors, pathogenesis, and antibiotic resistance in Staphylococcus aureus' in Reviews in Medical Microbiology in 2016.
referenceNwobodo DC, Ugwu MC, Anie CO, Al-Ouqaili MT, Ikem JC, Chigozie UV, et al. discussed antibiotic resistance challenges and emerging strategies in the Journal of Clinical Laboratory Analysis (2022).
claimInadequate systems for ensuring the quality and continuous supply of medications, ineffective surveillance and monitoring mechanisms, and insufficient control and preventive measures have facilitated the rise of antibiotic resistance, particularly in developing nations with deficient policies.
referenceWang et al. published 'Neglected drivers of antibiotic resistance: Survival of extended-spectrum β-lactamase-producing pathogenic Escherichia coli from livestock waste through dormancy and release of transformable extracellular antibiotic resistance genes under heat treatment' in Environmental Science & Technology in 2023.
Medicinal plants and human health: a comprehensive review of ... link.springer.com Nov 5, 2025 3 facts
perspectiveEl-Saadony et al. (2025) argue that the use of plant-derived medicinal compounds represents a notable progression in antimicrobial treatment, providing novel techniques to address the escalating issue of antibiotic resistance in clinical environments.
claimThe resurgence of interest in natural medicines is attributed to rising concerns regarding the adverse effects and expenses of synthetic medications, heightened knowledge of antibiotic resistance, and a cultural transition towards holistic and preventative healthcare methodologies according to Balkrishna et al. (2024).
referencePhytochemicals are being investigated as a potential solution for combating antibiotic resistance in microbial pathogens, as explored by Khare et al. (2021).
Pharmacological Uses of New Bioactive Compounds from Medicinal ... academia.edu 1 fact
claimNwobodo et al. reviewed antibiotic resistance challenges and emerging strategies for tackling the issue in 2022.
Pharmacological Uses of New Bioactive Compounds from Medicinal ... ouci.dntb.gov.ua 1 fact
claimAntibiotic resistance presents a global challenge, and emerging strategies are being developed to address this issue.
Healthy vs. Infected Wounds: A Clinician's Guide - Net Health nethealth.com Jun 24, 2025 1 fact
claimUsing antibiotics on healthy wounds is unnecessary and contributes to antibiotic resistance.