concept

ALKBH5

Also known as: RNA m6A demethylase ALKBH5, alkylated DNA base repair homolog 5

Facts (6)

Sources

Cellular senescence: from homeostasis to pathological implications ... frontiersin.org Frontiers 6 facts

claimRBM33 is an m(6)A RNA-binding protein that regulates ALKBH5 demethylase activity and substrate selectivity.

referenceYe G, Li J, Yu W, Xie Z, Zheng G, Liu W et al. reported in Experimental & Molecular Medicine (2023) that ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate mesenchymal stem cell (MSC) senescence and osteoarthritis progression.

referenceLi G, Luo R, Zhang W, He S, Wang B, Liang H et al. reported in Clinical and Translational Medicine (2022) that m6A hypomethylation of DNMT3B, regulated by ALKBH5, promotes intervertebral disc degeneration via E4F1 deficiency.

referenceLi S, Kang N, Wang R, Li M, Chen L, Zhou P et al. reported in the Journal of Hazardous Materials (2024) that ALKBH5 SUMOylation-mediated FBXW7 m6A modification regulates alveolar cell senescence during 1-nitropyrene-induced pulmonary fibrosis.

claimPost-translational modification of the RNA m6A demethylase ALKBH5 regulates the reactive oxygen species (ROS)-induced DNA damage response.

claimK235 acetylation couples with PSPC1 to regulate the m(6)A demethylation activity of ALKBH5 and tumorigenesis.