Knowledge Tree
ageing
Also known as: aging process
Facts (22)
Sources
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Mar 14, 2023 13 facts
referenceShpilka, T. and Haynes, C. M. published a study in 2018 titled 'The mitochondrial UPR: mechanisms, physiological functions and implications in ageing' in Nature Reviews Molecular Cell Biology, which reviews the mechanisms, physiological functions, and aging-related implications of the mitochondrial unfolded protein response.
referenceSIRT7 plays a role in the aging process, as detailed in a 2022 review by Lagunas-Rangel in Cellular and Molecular Life Sciences.
claimAltered intercellular communication is a hallmark of ageing, acting as a double-edged sword that contributes to both tissue homeostasis maintenance and age-related diseases.
referenceDNA damage responses and p53 are involved in the aging process, as reviewed by Ou and Schumacher in a 2018 article in Blood.
claimCellular senescence contributes significantly to ageing and ageing-related diseases, suggesting that targeting cellular senescence may allow for the reversal of ageing.
referenceCircadian aspects of energy metabolism are relevant to the aging process, as discussed by Froy in Ageing Research Reviews (2013).
referenceKane and Sinclair (2019) analyzed epigenetic changes that occur during the aging process and evaluated the potential for epigenetic reprogramming.
referenceCostantino, S., Paneni, F., and Cosentino, F. examined the relationship between ageing, metabolism, and cardiovascular disease.
claimClinical rejuvenation approaches to treat ageing-related diseases and reverse ageing are expected to develop significantly within the next two to three decades.
referenceFafian-Labora and O’Loghlen (2020) reviewed classical and nonclassical intercellular communication mechanisms in senescence and ageing.
claimPathological accumulation of senescent cells (SCs) is associated with ageing and a range of diseases, making them potential pharmacological targets for delaying the ageing process.
claimThe DNA repair response in stem cells declines with ageing, leading to the loss of stem cell properties, DNA damage-caused cellular senescence, and organ atrophy.
referenceMonti et al. (2021) explored whether extracellular vesicles serve as footprints of environmental exposures in the aging process.
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 2 facts
referenceInsulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway, which impacts the aging process and age-related diseases, according to Salminen et al. (2021).
referenceHou Y, Dan X, Babbar M, Wei Y, Hasselbalch SG, Croteau DL, et al. authored 'Ageing as a risk factor for neurodegenerative disease', published in Nature Reviews Neurology in 2019 (15:565–81, doi: 10.1038/s41582-019-0244-7).
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 1 fact
referenceP. Yaqoob published 'Ageing, immunity and influenza: a role for probiotics?' in the Proceedings of the Nutrition Society in 2014.
Chronic Inflammation: How to Test For it and Prevent it medichecks.com Jan 31, 2024 1 fact
referenceThe National Center for Biotechnology Information (NCBI) published 'Inflammation, Ageing, and Chronic Disease' in Open Biology on September 15, 2021.
Recent breakthroughs in the valorization of lignocellulosic biomass ... pubs.rsc.org Jun 7, 2025 1 fact
referenceA. Bentur and S. A. S. Akerst examined the microstructure and ageing of cellulose fibre reinforced cement composites cured in a normal environment in a 1989 paper published in the International Journal of Cement Composites and Lightweight Concrete.
Developing youth work: Chapter 5 - Beyond social education infed.org 1 fact
claimLife events including parenthood, the aging process, changes in relationships, the death of parents and friends, and changes in work affect how individuals perceive themselves and how they are perceived by others.
How Testosterone Changes Affect Men's Health as You Age columbiadoctors.org Dec 16, 2025 1 fact
claimMen can maintain their health during the aging process by maintaining healthy lifestyle habits, staying connected with others, finding meaning and purpose, and seeking professional help when needed.
Telomere Biology, Erosion, and Age-Related Conditions link.springer.com Aug 1, 2025 1 fact
claimBlackburn, Epel, and Lin (2015) proposed that human telomere biology acts as both a contributory and interactive factor in the aging process, disease risks, and biological protection mechanisms.
Understanding Male Hormonal Changes: A Complete Guide (2025) coremedicalwellness.com Oct 21, 2025 1 fact
claimHormonal changes are a normal part of the aging process in men, though significant imbalances affecting quality of life may benefit from medical treatment.