concept

age-related macular degeneration

Also known as: AMD

Facts (9)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 9 facts

claimSenolytics, which kill senescent cells and stop the bystander effects of the senescence-associated secretory phenotype (SASP), are a potential treatment for age-related macular degeneration (AMD) due to the role of cellular senescence in its pathogenesis.

claimAge-related macular degeneration (AMD) is an eye condition characterized by photoreceptor loss and the degeneration of the choriocapillaris and retinal pigment epithelium (RPE).

measurementNicotinamide mononucleotide (NMN) alleviates retina damage, reduces DNA damage by 50%, and eliminates senescent cells (SCs) in age-related macular degeneration models.

claimInduced pluripotent stem cell (iPSC)-based treatment of age-related macular degeneration requires more than blind faith to succeed, according to Li, Hu, and He in Genes & Diseases (2017).

claimZhang, Z. Y. et al. identified autophagy as a regulatory mechanism of oxidative stress in age-related macular degeneration.

claimThe interaction between the NFE2L2, PGC-1, p62, AMPK, and PI3K/Akt/mTOR pathways is considered important for autophagy-based rejuvenative strategies in age-related macular degeneration (AMD).

claimPotential rejuvenative strategies for alleviating age-related macular degeneration (AMD) include the use of mTOR inhibitors, hormones, melatonin, and dietary antioxidants to activate autophagy.

claimEnhancing autophagy can resist oxidative damage and mitigate the progression of age-related macular degeneration (AMD).

claimAge-related macular degeneration (AMD) is primarily attributed to oxidative stress, cellular senescence, and inflammation.