concept

adult stem cells

Facts (13)

Sources

Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com Nature Mar 14, 2023 8 facts

claimExtracellular signaling molecules, including extracellular vesicles (EVs), neurotransmitters, growth factors, hormones, and cytokines, function as cues to transmit information to target somatic cells or adult stem cells.

claimFu et al. discovered that epidermal cells can de-differentiate into stem cells in vivo during wound healing, demonstrating that adult cells can become adult stem cells and that cellular fate is not a one-way street.

claimWeeden and Asselin-Labat (2018) established that DNA damage repair mechanisms in adult stem cells have significant implications for cancer formation.

claimMetabolic disturbance drives the functional decline of adult stem cells during aging, with nutrient-sensitive signaling pathways like mTOR and AMPK playing a central role.

claimAdult stem cells, such as hematopoietic stem cells (HSCs) and bone marrow mesenchymal stem cells (BMSCs), live in hypoxic conditions in vivo.

claimPei M. demonstrated that environmental preconditioning rejuvenates the proliferation and chondrogenic potential of adult stem cells in a 2017 study published in Biomaterials.

referenceLananna and Musiek (2015) published 'The circadian clock in skin: implications for adult stem cells, tissue regeneration, cancer, aging, and immunity' in Journal of Biological Rhythms, detailing the role of circadian clocks in skin physiology.

claimReprogramming-derived stem cells are more amenable to genetic correction and more homogeneous than isolated adult stem cells, but their application is limited by low reprogramming efficacy and potential security concerns.

Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Springer Apr 16, 2018 5 facts

claimAn increase in reactive oxygen species (ROS), independent of oxidative phosphorylation (OXPHOS), promotes the differentiation of pluripotent stem cells and adult stem cells, including mesenchymal stem cells (MSCs), hematopoietic stem cells (HSCs), and neural stem cells (NSCs).

claimPhysiological oxygen levels are present in the in vivo niches of adult stem cells, including hematopoietic stem cells (HSCs), mesenchymal stem cells (MSCs), and neural stem cells (NSCs).

claimThe regulation of intracellular calcium is considered crucial for the physiological differentiation of pluripotent stem cells (PSCs) and adult stem cells, including mesenchymal stem cells (MSCs) and neural stem cells (NSCs).

claimAdult stem cells, including hematopoietic stem cells (HSCs) and neural stem cells (NSCs), depend on glycolysis for energy despite having low proliferative rates or being quiescent.

claimAdult stem cells are generally considered more resistant to cell death than pluripotent stem cells, though they may still undergo cell death in response to DNA damage.