concept

adult neurogenesis

Also known as: adult brain neurogenesis

Facts (15)

Sources

Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Springer Dec 19, 2024 14 facts

referenceBarnea and Pravosudov (2011) proposed using birds as a model to study adult neurogenesis, bridging evolutionary, comparative, and neuroethological approaches.

claimJacobs, van Praag, and Gage (2000) proposed a theory of depression based on adult brain neurogenesis and psychiatry.

claimPsychedelic compounds, including phenethylamines, tryptamines, and cannabinoids, are considered therapeutic options for neuropsychiatric disorders, with reports linking them to increased adult neurogenesis.

claimKetamine is recognized for positively influencing adult neurogenesis subprocesses, including proliferation, differentiation, and survival of new neurons, through the upregulation of BDNF.

claimIn rodents, adult neurogenesis is restricted to the olfactory bulb, driven by neural stem cells in the subventricular zone, and the dentate gyrus sub-region of the hippocampus, driven by radial glial-like cells.

referenceM. Petermann et al. found that alterations in BDNF protein concentrations in the hippocampus do not explain the pro-neurogenic effect of Citalopram on adult neurogenesis, as published in Pharmacopsychiatry in 2021.

claimThe dentate gyrus is the primary site of adult neurogenesis in the mammalian hippocampus.

claimThe study by Liu et al. (2006) on phencyclidine (PCP) exposure lacks detailed information on the exact age of the animals, which is a factor that strongly influences adult neurogenesis.

claimPsychedelics possess a significant capacity to enhance adult neurogenesis and neural plasticity.

claimIn the mammalian brain, new neurons are generated throughout life in a process known as adult neurogenesis.

measurementChronic citalopram treatment over 21 days enhanced adult neurogenesis in control mice without affecting BDNF protein levels.

referenceBarker, Boonstra, and Wojtowicz (2011) explored how comparative studies contribute to understanding the function of adult neurogenesis.

claimAdult neurogenesis is the biological process by which new neurons are generated within specific brain niches throughout the life of an organism.

accountAltman and Das first evidenced adult neurogenesis, the process by which new neurons are continuously added to the brain, in 1965 through autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats.

Editorial: Inflammation and chronic disease - Frontiers frontiersin.org Frontiers Jul 1, 2024 1 fact

referenceNeuroinflammation and adult neurogenesis have a bidirectional relationship, with mechanisms involved in this dialogue contributing to alterations in neurological diseases, as reviewed by Amanollahi et al. in 2023.