concept

acetyl-CoA

Also known as: acetyl-coenzyme A

Facts (7)

Sources

Mitochondria and the dynamic control of stem cell homeostasis link.springer.com Springer Apr 16, 2018 5 facts

referenceMoussaieff et al. (2015) showed that glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells.

claimCitrate is a tricarboxylic acid (TCA) cycle metabolite associated with epigenetic modulation; it can be exported from mitochondria and converted into acetyl-CoA by the enzyme ATP-citrate lyase (ACL).

referenceSutendra G et al. found in 2014 that a nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation.

claimHigh levels of acetyl-CoA induce the expression of proliferation-related genes in yeast, a response relevant to cancer transformation.

referenceCai et al. (2011) demonstrated that Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes.

Medicinal plants: bioactive compounds, biological activities ... frontiersin.org Frontiers in Immunology 1 fact

claimTerpenoids originate metabolically from acetyl-CoA or glycolytic intermediates.

Dietary interventions as regulators of stem cell behavior in ... genesdev.cshlp.org Genes & Development 1 fact

claimKetone bodies enter the tricarboxylic acid (TCA) cycle as acetyl-CoA, bypassing glucose oxidation, which is typically a major source of acetyl-CoA in cells, according to Shi and Tu (2015).