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A Synergistic Workspace for Human Consciousness Revealed by...

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A Synergistic Workspace for Human Consciousness Revealed by ... elifesciences.org eLife 21 facts
procedureThe researchers of 'A Synergistic Workspace for Human Consciousness Revealed by...' preprocessed DOC patients' brains individually using SPM12 with visual inspections after each step to account for deformations caused by brain injury, rather than using automated pipelines.
procedureTo reduce movement artefacts, the researchers of 'A Synergistic Workspace for Human Consciousness Revealed by...' used the aCompCor denoising procedure and despiking with a hyperbolic tangent squashing function implemented from the CONN toolbox.
claimIn the study 'A Synergistic Workspace for Human Consciousness Revealed by...', the anaesthesia level was assessed by two anaesthesiologists and one anaesthesia nurse who could not be blinded to the experimental condition because their role involved determining the participants' level of anaesthesia.
procedureTo ensure robustness, the researchers of 'A Synergistic Workspace for Human Consciousness Revealed by...' replicated results using an alternative parcellation consisting of the Schaefer scale-200 cortical parcellation and the scale-32 subcortical ROIs from the Tian subcortical atlas.
procedureParticipants in the study 'A Synergistic Workspace for Human Consciousness Revealed by...' were evaluated for responsiveness using a test of verbal memory recall and a computer-based auditory target-detection task, with wakefulness also monitored via an infrared camera inside the scanner.
procedureThe researchers of 'A Synergistic Workspace for Human Consciousness Revealed by...' deconvolved the hemodynamic response function from regional BOLD signal timeseries prior to analysis using a dedicated toolbox.
measurementDuring the study 'A Synergistic Workspace for Human Consciousness Revealed by...', the mean estimated effect-site propofol concentration was 2.48 µg mL-1 (range 1.82-3.14 µg mL-1) and the mean estimated plasma propofol concentration was 2.68 µg mL-1 (range 1.92-3.44 µg mL-1) at Ramsay level 5.
procedurePropofol administration in the study 'A Synergistic Workspace for Human Consciousness Revealed by...' utilized an AS50 auto syringe infusion pump (Baxter Healthcare, Singapore) and the TIVA Trainer (European Society for Intravenous Anaesthesia) pharmacokinetic simulation program to achieve target-controlled infusion.
procedureThe researchers of 'A Synergistic Workspace for Human Consciousness Revealed by...' parcellated brains into 454 cortical and subcortical regions of interest (ROIs), consisting of 400 cortical ROIs from the Schaefer scale-400 parcellation and 54 subcortical ROIs from the Tian parcellation.
referenceThe TIVA Trainer pharmacokinetic simulation program used in the study 'A Synergistic Workspace for Human Consciousness Revealed by...' followed the Marsh 3-compartment model to specify blood concentrations of propofol for target-controlled infusion.
claimIn the study 'A Synergistic Workspace for Human Consciousness Revealed by...', Ramsay sedation level 5 was defined as the state where participants stopped responding to verbal commands, were unable to engage in conversation, and were rousable only to physical stimulation.
measurementIn the study 'A Synergistic Workspace for Human Consciousness Revealed by...', data from 3 participants (1 male) were excluded from analysis due to equipment malfunction or physiological impediments to anaesthesia in the scanner, resulting in a final sample size of 16 participants.
procedureThe study 'A Synergistic Workspace for Human Consciousness Revealed by...' acquired resting-state fMRI data at two propofol levels: no sedation (Awake) and Deep anaesthesia (Ramsay score of 5).
claimThe authors of 'A Synergistic Workspace for Human Consciousness Revealed by...' observed that disruptions in information integration during loss of consciousness are localized in gateway nodes rather than broadcaster nodes.
perspectiveThe authors of 'A Synergistic Workspace for Human Consciousness Revealed by...' do not use the integrated information measure proposed in IIT 3.0 because it is computationally intractable for systems larger than a small set of logic gates and is not universally well-defined.
claimThe authors of 'A Synergistic Workspace for Human Consciousness Revealed by...' identify Default Mode Network (DMN) nodes as gateways for inputs to the synergistic global workspace.
claimThe authors of 'A Synergistic Workspace for Human Consciousness Revealed by...' found that brain regions exhibiting consciousness-specific reductions in integrated information correspond to major nodes of the synergistic global workspace.
claimThe authors of the paper 'A Synergistic Workspace for Human Consciousness Revealed by...' declare no competing interests.
perspectiveThe study 'A Synergistic Workspace for Human Consciousness Revealed by...' contributes to the conceptual and empirical reconciliation between the Global Neuronal Workspace theory and Integrated Information Theory.
procedureThe authors of 'A Synergistic Workspace for Human Consciousness Revealed by...' addressed potential confounds in their fMRI data by deconvolving the hemodynamic response function using a dedicated toolbox.
claimThe authors of 'A Synergistic Workspace for Human Consciousness Revealed by...' expanded Shanahan's connective core hypothesis by applying information-theoretic tools to analyze the core from a functional, information-centric perspective.