concept

5-methoxy-N,N-dimethyltryptamine

Also known as: 5-MeO-DMT

Facts (10)

Sources

Published Studies — Johns Hopkins Center for Psychedelic and ... hopkinspsychedelic.org Johns Hopkins Center for Psychedelic and Consciousness Research 8 facts

referenceOrtiz Bernal, A. M., Raison, C. L., Lancelotta, R. L., and Davis, A. K. published 'Reactivations after 5-methoxy-N,N-dimethyltryptamine use in naturalistic settings: An initial exploratory analysis of the phenomenon’s predictors and its emotional valence' in Frontiers in Psychiatry in 2022.

referenceA 2018 study by Davis, Barsulglia, Lancelotta, Grant, and Renn published in the Journal of Psychopharmacology examined the epidemiology of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) use, including benefits, consequences, patterns of use, subjective effects, and reasons for consumption.

referenceA prospective examination of synthetic 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) inhalation found effects on salivary IL-6, cortisol levels, affect, and non-judgment.

claimThe use of benefit enhancement strategies among 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) users is associated with mystical, challenging, and enduring effects.

referenceA 2019 study by Sepeda, Clifton, Doyle, Lancelotta, Griffiths, and Davis found that inhaled 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is associated with positive acute and enduring effects when used in a supportive context.

referenceA 2019 study by Davis, So, Lancelotta, Barsuglia, and Griffiths found that the use of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic group setting is associated with unintended improvements in depression and anxiety.

referenceA 2020 study by Uthaug, Lancelotta, Ortiz Bernal, Davis, and Ramaekers compared reactivation experiences following vaporization and intramuscular injection of synthetic 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting.

referenceReckweg, J. T., Uthaug, M. V., Szabo, A., Davis, A. K., Lancelotta, R., Mason, N. L., and Ramaekers, J. G. published a study in the Journal of Neurochemistry in 2022 regarding the clinical pharmacology and potential therapeutic applications of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT).

Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com Springer Dec 19, 2024 2 facts

claim5-Methoxy-N, N-dimethyltryptamine (5-MeO-DMT) is an indole alkaloid and a structural analog of DMT found in the venom of the Incilius alvarius toad.

claimThe serotonergic hallucinogen 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) disrupts cortical activity in a regionally-selective manner via 5-HT1A and 5-HT2A receptors, as reported by Riga et al. in Neuropharmacology (2016).