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1,25-dihydroxyvitamin D3
Also known as: 1,25-dihydroxyvitamin D, 1,25-dihydroxyvitamin D3, 1,25-dihydroxy vitamin D
Facts (19)
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Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 18 facts
claim1,25-dihydroxyvitamin D3 inhibits the development and function of Th1 cells, but enhances the development and function of Th2 cells and regulatory T cells.
claim1,25-dihydroxyvitamin D3 modulates both innate and adaptive immune responses.
referenceCantorna MT, Woodward WD, Hayes CE, and DeLuca HF published '1,25-dihydroxyvitamin D3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-beta 1 and IL-4' in The Journal of Immunology in 1998 (volume 160, issue 11, pages 5314-5319), identifying 1,25-dihydroxyvitamin D3 as a positive regulator of TGF-beta 1 and IL-4.
measurementVDR activation by 1,25-dihydroxyvitamin D is thought to directly or indirectly regulate between 100 and 1,250 genes.
referenceMathieu C and Adorini L published 'The coming of age of 1,25-dihydroxyvitamin D(3) analogs as immunomodulatory agents' in Trends in Molecular Medicine in 2002 (volume 8, issue 4, pages 174-179), discussing the use of 1,25-dihydroxyvitamin D3 analogs as immunomodulators.
referenceMuller K, Odum N, and Bendtzen K published '1,25-dihydroxyvitamin D3 selectively reduces interleukin-2 levels and proliferation of human T cell lines in vitro' in Immunology Letters in 1993 (volume 35, issue 2, pages 177-182), reporting that 1,25-dihydroxyvitamin D3 reduces interleukin-2 levels and proliferation in human T cell lines.
procedureThe VDR/RXR complex binds to small DNA sequences known as vitamin D response elements (VDREs) in the presence of 1,25-dihydroxyvitamin D3, initiating a cascade of molecular interactions that modulate the transcription of specific genes.
claim1,25-dihydroxyvitamin D3 modulates the functional phenotype of helper T cells and dendritic cells.
claim1,25-dihydroxyvitamin D3 is a modulator of the immune system in addition to its roles in mineral homeostasis and bone metabolism.
referenceThe human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3, according to a 2005 study in the FASEB Journal.
referenceMuller K, Heilmann C, Poulsen LK, Barington T, and Bendtzen K published 'The role of monocytes and T cells in 1,25-dihydroxyvitamin D3 mediated inhibition of B cell function in vitro' in Immunopharmacology in 1991 (volume 21, issue 2, pages 121-128), examining the role of monocytes and T cells in the inhibition of B cell function by 1,25-dihydroxyvitamin D3.
claimThe active form of vitamin D, 1,25-dihydroxyvitamin D3, functions as a steroid hormone to regulate the expression of target genes.
claimMany biological effects of 1,25-dihydroxyvitamin D3 are mediated through the vitamin D receptor (VDR), which is a nuclear transcription factor.
referenceChen WC, Vayuvegula B, and Gupta S published '1,25-Dihydroxyvitamin D3-mediated inhibition of human B cell differentiation' in Clinical & Experimental Immunology in 1987 (volume 69, issue 3, pages 639-646), reporting that 1,25-dihydroxyvitamin D3 inhibits human B cell differentiation.
procedureUpon entering a cell nucleus, 1,25-dihydroxyvitamin D3 associates with the vitamin D receptor (VDR) and promotes the association of the VDR with the retinoid X receptor (RXR).
referenceHuman peripheral blood mononuclear cells possess high-affinity receptors for 1,25-dihydroxyvitamin D3, specifically in monocytes, and these receptors are induced in T lymphocytes following activation, according to a 1983 study in the Journal of Clinical Endocrinology and Metabolism.
referenceLemire JM, Archer DC, Beck L, and Spiegelberg HL published 'Immunosuppressive actions of 1,25-dihydroxyvitamin D3: preferential inhibition of Th1 functions' in The Journal of Nutrition in 1995 (volume 125, issue 6 Suppl, pages 1704S-1708S), noting that 1,25-dihydroxyvitamin D3 preferentially inhibits Th1 immune functions.
claim1,25-dihydroxyvitamin D3 suppresses antibody production by B cells and inhibits the proliferation of T cells in vitro.
Phytochemical and Pharmacological Studies of Traditionally Used ... heraldopenaccess.us 1 fact
claimRasheed, Oraby, and Hussein (2009) reported the therapeutic efficacy of garlic oil combined with 1,25-dihydroxy vitamin D and calcium in treating osteoporotic ovariectomized rats.