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The Improved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) and the Pravastatin or Atorvastatin Evaluation and Infection Therapy Trial (PROVE-IT) showed that patients who met both targets of low-density lipoprotein cholesterol (LDL-C) <70 mg/dL and high-sensitivity C-reactive protein (hs-CRP) <2 mg/L had the best clinical outcomes.

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