Leukemia cells up-regulate the enzyme BCAT1, which depletes alpha-ketoglutarate (αKG), resulting in the inhibition of ten-eleven translocation (Tet) DNA demethylases and subsequent DNA hypermethylation.

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• Person: Not available Organization: Genes & Development
  Dietary interventions as regulators of stem cell behavior in ...

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• Dietary interventions as regulators of stem cell behavior in ... genesdev.cshlp.org Genes & Development via serper

Referenced by nodes (1)

• α-ketoglutarate concept