Braak and colleagues (2004) found that Lewy body degeneration begins in the lower brainstem and ascends to involve the substantia nigra only after several years, which is consistent with observations that REM sleep alterations may precede movement disorders by several years in many Parkinson’s disease patients.

Authors

• Person: Colten HR, Altevogt BM Organization: National Academies Press
  Extent and Health Consequences of Chronic Sleep Loss and ... - NCBI

Sources

• Extent and Health Consequences of Chronic Sleep Loss and ... - NCBI www.ncbi.nlm.nih.gov Colten HR, Altevogt BM · National Academies Press via serper

Referenced by nodes (4)

• REM sleep concept
• Parkinson's disease concept
• brainstem concept
• substantia nigra concept