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Relations (1)
related 4.09 — strongly supporting 16 facts
Macrophages and B cells are both types of white blood cells {fact:2, fact:8} that function as antigen-presenting cells {fact:7, fact:12} and share the ability to produce various cytokines such as IL-38 {fact:5, fact:6} and IL-10 [1]. Furthermore, they interact within the immune system where B cells produce antibodies to mark pathogens for destruction by macrophages [2], and both are targets for regulation by T cell signaling {fact:3, fact:4, fact:11}.
Facts (16)
Sources
Pro-Inflammatory Cytokines Overview | Thermo Fisher Scientific - US thermofisher.com 7 facts
referenceIL-4 is classified as an adaptive immunity cytokine, is produced by Th cells, binds to the CD124 receptor, targets B cells, T cells, and macrophages, and functions in the proliferation of B and cytotoxic T cells, enhancement of MHC class II expression, and stimulation of IgG and IgE production.
claimIL-6 is produced by monocytes, fibroblasts, and endothelial cells, and upon stimulation, it is secreted by macrophages, T cells, B cells, mast cells, glial cells, eosinophils, keratinocytes, and granulocytes.
referenceIL-10 is classified as an anti-inflammatory cytokine, is produced by T cells, B cells, and macrophages, binds to the CDw210 receptor, targets B cells and macrophages, and functions to inhibit cytokine production and mononuclear cell function.
referenceIL-6 is classified as a pro-inflammatory cytokine, is produced by Th cells, macrophages, and fibroblasts, binds to CD126 and CD130 receptors, targets B cells and plasma cells, and functions in B-cell differentiation.
claimB cells and macrophages produce IL-38, which inhibits IL-1, IL-6, IL-17, IL-22, and TNF.
claimInterleukin-38 (IL-38/IL-1F10) is an anti-inflammatory cytokine produced by B cells and macrophages that binds to the IL-1R1 receptor.
referenceIL-1 is classified as a pro-inflammatory cytokine, is produced by macrophages, B cells, and dendritic cells, binds to the CD121a receptor, targets B cells, NK cells, and T cells, and functions in pyrogenic activity, inflammation, cell proliferation, differentiation, and bone marrow cell proliferation.
Parts of the Immune System | Children's Hospital of Philadelphia chop.edu 3 facts
procedureDendritic cells, macrophages, and B cells must travel to the draining lymph node to activate the adaptive immune response when acting as antigen-presenting cells.
claimDendritic cells, macrophages, and B cells are the three cell types that can serve as antigen-presenting cells (APCs).
claimHelper T cells oversee cytokine signaling to activate B cells and increase the efficiency of other immune cells, such as macrophages.
The components of the immune system - Immunobiology - NCBI - NIH ncbi.nlm.nih.gov 2 facts
claimT lymphocytes (T cells) consist of two main classes: cytotoxic T cells, which kill virus-infected cells, and a second class that activates other cells such as B cells and macrophages.
claimT lymphocytes (T cells) consist of two main classes: cytotoxic T cells, which kill virus-infected cells, and a second class that activates other cells, including B cells and macrophages.
Immunity In Depth | Linus Pauling Institute lpi.oregonstate.edu 2 facts
claimT cells expressing the cell-surface protein CD4 are divided into two subsets: T helper (Th)1 cells, which are primarily involved in activating macrophages and inflammatory responses, and Th2 cells, which are primarily involved in stimulating antibody production by B cells.
claimB cells produce antibodies, which are specialized proteins that recognize and bind to foreign proteins or pathogens to neutralize them or mark them for destruction by macrophages; this response is called humoral immunity.
The immune system and primary immunodeficiency primaryimmune.org 1 fact
claimThe most common cells of the immune system are lymphocytes (T cells, B cells, and NK cells), neutrophils, and monocytes/macrophages, all of which are types of white blood cells.
How the Immune System Works with Primary Immunodeficiency igcares.com 1 fact
claimThe immune system consists of white blood cells categorized as lymphocytes (T-cells, B-cells, and NK cells), neutrophils, and monocytes/macrophages.