Knowledge Tree
Relations (1)
cross_type 2.32 — strongly supporting 4 facts
Bone marrow serves as the site of origin for all cellular elements of the blood, including hematopoietic stem cells [1], and acts as a primary location for the maturation and migration of immune cells that travel through the blood to peripheral tissues {fact:1, fact:4}. Additionally, both locations serve as reservoirs for mature T cells [2].
Facts (4)
Sources
The components of the immune system - Immunobiology - NCBI - NIH ncbi.nlm.nih.gov 2 facts
claimAll cellular elements of blood, including red blood cells, platelets, and white blood cells, derive from hematopoietic stem cells located in the bone marrow.
claimImmune system cells originate in the bone marrow, where many of them also mature, before migrating to guard peripheral tissues via the blood and the lymphatic system.
The immune system and primary immunodeficiency primaryimmune.org 1 fact
claimMature T cells leave the thymus as naïve T cells and populate organs such as the spleen, lymph nodes, bone marrow, and blood, where they may become memory T cells after antigen exposure.
Parts of the Immune System | Children's Hospital of Philadelphia chop.edu 1 fact
procedureDendritic cells are produced in bone marrow, migrate through the blood to tissues to monitor for pathogens, and upon encountering a pathogen, phagocytose it and present pieces of it as antigens on their surface.