obstructive sleep apnea ↔ glucose intolerance

Relations (1)

related 2.32 — strongly supporting 4 facts

Obstructive sleep apnea is linked to glucose intolerance as a pathophysiological precursor to diabetes, as evidenced by [1] and [2]. Furthermore, [3] identifies both as independent risk factors for cardiovascular disease, while [4] explains that the physiological stress responses triggered by OSA directly mediate the development of glucose intolerance.

Facts (4)

Sources

Extent and Health Consequences of Chronic Sleep Loss and ... - NCBI ncbi.nlm.nih.gov Colten HR, Altevogt BM · National Academies Press 4 facts

claimThe activation of the sympathetic nervous system, hypothalamic-pituitary-adrenal axis, and adipocytes due to Obstructive Sleep Apnea (OSA) leads to the release of catecholamines, cortisol, and inflammatory cytokines, which may mediate the development of glucose intolerance, insulin resistance, and type 2 diabetes.

claimObstructive sleep apnea contributes to the onset of diabetes through the development of glucose intolerance and insulin resistance, which are established pathophysiological processes in diabetes, according to Martin et al. (1992).

claimObstructive Sleep Apnea (OSA) contributes to the onset of diabetes through the development of glucose intolerance and insulin resistance.

claimObstructive sleep apnea is associated with glucose intolerance and diabetes, both of which are independent risk factors for cardiovascular disease.