Knowledge Tree
Relations (1)
related 3.91 — strongly supporting 11 facts
Aging and cancer are intrinsically linked through shared biological mechanisms such as cellular senescence [1], [2], mitochondrial DNA methylation [3], and metabolic signaling pathways [4], [5]. Furthermore, both processes are influenced by common factors like inflammation [6], autophagy [7], and circadian rhythm disruptions [8], [9].
Facts (11)
Sources
Cellular rejuvenation: molecular mechanisms and potential ... - Nature nature.com 4 facts
referenceLibby, P. and Kobold, S. published a study in 2019 titled 'Inflammation: a common contributor to cancer, aging, and cardiovascular diseases-expanding the concept of cardio-oncology' in Cardiovascular Research, which posits inflammation as a common factor contributing to cancer, aging, and cardiovascular diseases.
referenceSirtuins, melatonin, and circadian rhythms are interconnected in the context of aging and cancer, as discussed by Jung-Hynes, Reiter, and Ahmad in the Journal of Pineal Research (2010).
referenceLananna and Musiek (2015) published 'The circadian clock in skin: implications for adult stem cells, tissue regeneration, cancer, aging, and immunity' in Journal of Biological Rhythms, detailing the role of circadian clocks in skin physiology.
claimMenendez and Alarcon (2017) discuss the senescence-inflammatory regulation of reparative cellular reprogramming in the contexts of aging and cancer.
Cellular senescence: from homeostasis to pathological implications ... frontiersin.org 4 facts
claimAutophagy functions at the intersection of aging, senescence, and cancer.
claimThe article "Cellular senescence: from homeostasis to pathological implications and therapeutic strategies" addresses the topics of cellular senescence, cancer, m6A RNA methylation, aging, longevity, and inflammation.
referenceV.N. Anisimov published 'Insulin/IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention' in Experimental Gerontology in 2003, which explores the insulin/IGF-1 signaling pathway as a target for pharmacological intervention in aging and cancer.
claimMetabolic programs tailor T cell immunity in the contexts of viral infection, cancer, and aging.
Chronic inflammation in the etiology of disease across the life span nature.com 1 fact
claimCellular senescence is a factor in aging and cancer, as detailed in a 2013 review in the Annual Review of Physiology.
Should you be tested for inflammation? health.harvard.edu 1 fact
claimStamping out inflammation would not eliminate cardiovascular disease, cancer, dementia, or aging.
Peer-Reviewed Papers - The Levin Lab drmichaellevin.org 1 fact
referencePio-Lopez, L., and Levin, M. published 'Morphoceuticals: Perspectives for discovery of drugs targeting anatomical control mechanisms in regenerative medicine, cancer and aging' in Drug Discovery Today in 2023.