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related 3.32 — strongly supporting 9 facts
The prefrontal cortex and hippocampus are functionally linked as key brain regions involved in memory, executive function, and emotional regulation, as evidenced by their shared vulnerability to toxic stress [1], [2], [3] and their co-modulation by pharmacological treatments [4], [5], [6]. Furthermore, they are frequently studied together as part of the neural networks underlying meditation [7], emotion regulation [8], and ego-related cognitive states [9].
Facts (9)
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Effects of psychedelics on neurogenesis and broader neuroplasticity link.springer.com 3 facts
measurementLiu and colleagues found that 20 mg/kg of harmine increased BDNF levels in the hippocampus and prefrontal cortex, as well as glutamate transporter 1 (GLT-1) expression levels in mice.
claimChronic THC exposure during adolescence reduces BDNF levels via the CREB pathway in the hippocampus and prefrontal cortex of male rats, while paradoxically increasing BDNF in the nucleus accumbens of female rats.
accountWankhar et al. (2020) demonstrated that 1-Methylpsilocin treatment alleviated behavioral signs of anxiety and anhedonic phenotype by the seventh day post-CUS, rescued subjects from CUS-induced mitochondrial damage, balanced 5-HT/5-HT2CR levels in the PFC and hippocampus, and mitigated hippocampal cell morphological abnormalities and elevated corticosterone levels.
Implications for Mental Health and Coping Strategies | OxJournal oxjournal.org 2 facts
claimProlonged exposure to cyberbullying acts as a source of toxic stress that can increase the size of the limbic system while decreasing the size and impairing the functioning of the prefrontal cortex and hippocampus.
claimToxic stress impairs the functioning of the prefrontal cortex and the hippocampus, which are regions of the brain responsible for memory, learning, and executive functioning.
Self-awareness, self-regulation, and self-transcendence (S-ART) frontiersin.org 2 facts
referenceBrain areas critical for their interactions with the prefrontal cortex (PFC) in emotion regulation include the amygdala, hippocampus, striatum (including the nucleus accumbens), thalamus, and insula.
measurementAdept practitioners of Zen meditation show reduced activity in executive, evaluative, and emotion-related brain areas (prefrontal cortex, amygdala, hippocampus) during acute pain compared to control subjects, according to Grant et al. (2010b).
The Effects of Attachment and Trauma on Parenting and Children's ... rsisinternational.org 1 fact
referenceTrauma alters the architecture of brain regions responsible for emotional regulation and memory, specifically the amygdala, hippocampus, and prefrontal cortex, which compromises a child's ability to process threats or connect emotionally, according to Van der Kolk (2014).
The Mechanisms of Psychedelic Visionary Experiences - Frontiers frontiersin.org 1 fact
claimEgoless experiences, measured as 'oceanic boundlessness,' are associated with alterations in the frontolimbic-parieto-striatal network and are positively correlated with cerebral glucose metabolism in Default Mode Network regions (anterior cingulate cortex, hippocampus, inferior parietal cortex) and prefrontal cortex areas (frontomedial superior, frontolateral, and left inferolateral).