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Relations (1)
related 3.00 — strongly supporting 7 facts
The spleen is anatomically and functionally linked to blood as it filters circulating blood to detect pathogens [1], removes senescent red blood cells [2], and serves as a site for immune cell interaction and circulation {fact:1, fact:2, fact:7}. Additionally, a significant portion of cardiac output flows through the spleen [3], and monocytes within the spleen interact with microorganisms present in the blood [4].
Facts (7)
Sources
The immune system and primary immunodeficiency primaryimmune.org 2 facts
claimMature T cells leave the thymus as naïve T cells and populate organs such as the spleen, lymph nodes, bone marrow, and blood, where they may become memory T cells after antigen exposure.
claimMonocytes line the walls of blood vessels in organs like the liver and spleen to capture microorganisms passing through the blood.
Parts of the Immune System | Children's Hospital of Philadelphia chop.edu 2 facts
measurementApproximately 25 percent of the blood that comes from the heart flows through the spleen on every beat.
claimThe spleen filters circulating blood to detect pathogens, which triggers the activation and multiplication of immune system cells to neutralize those pathogens.
The components of the immune system - Immunobiology - NCBI - NIH ncbi.nlm.nih.gov 2 facts
claimThe spleen is a fist-sized organ located behind the stomach that collects antigen from the blood and disposes of senescent red blood cells.
procedureNaive lymphocytes circulate continually from the blood into peripheral lymphoid tissues by squeezing between capillary wall cells, and return to the blood via lymphatic vessels or directly from the spleen.
How the Immune System Works with Primary Immunodeficiency igcares.com 1 fact
claimThe spleen is a collection of T-lymphocytes, B-lymphocytes, and monocytes that filters the blood and provides a site for immune system cells and organisms to interact.