neuroplasticity ↔ depression

Relations (1)

related 2.00 — strongly supporting 3 facts

Depression and neuroplasticity are linked as serotonergic psychedelics are proposed to treat depression by leveraging neuroplasticity [1], while chronic stress-induced depression is associated with reduced neuroplasticity in dopaminergic neurons [2]. Furthermore, research indicates that serotonin levels influence both the vulnerability to depression and the capacity for neuroplastic recovery [3].

Facts (3)

Sources

Integrating allostasis and emerging technologies to study complex ... nature.com Nature 1 fact

accountCavalleri et al. modeled chronic stress and depression by exposing iPSC-derived dopaminergic neurons to high cortisol levels, observing structural changes and reduced neuroplasticity.

Psychedelics, Sociality, and Human Evolution frontiersin.org Frontiers 1 fact

claimI. Branchi described neural plasticity as a double-edged sword, noting that increasing serotonin levels leads to both greater vulnerability to depression and an improved capacity to recover, in a 2011 study.

Neuroimaging in psychedelic drug development: past, present, and ... nature.com Nature 1 fact

claimSerotonergic psychedelics may treat depression through the mechanism of neuroplasticity.